Open Access
疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
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TLDR
PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.Abstract:
抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。read more
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High-flux solar-driven thermochemical dissociation of CO2 and H2O using nonstoichiometric ceria
William C. Chueh,Christoph Falter,Mandy Abbott,Danien Scipio,Philipp Furler,Sossina M. Haile,Aldo Steinfeld,Aldo Steinfeld +7 more
TL;DR: By using a solar cavity-receiver reactor, the oxygen uptake and release capacity of cerium oxide and facile catalysis at elevated temperatures to thermochemically dissociate CO2 and H2O, yielding CO andH2, respectively were combined and stable and rapid generation of fuel was demonstrated over 500 cycles.
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Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle
Karine G. Le Roch,Yingyao Zhou,Peter L. Blair,Muni Grainger,J. Kathleen Moch,J. David Haynes,Patricia de la Vega,Anthony A. Holder,Serge Batalov,Daniel J. Carucci,Elizabeth A. Winzeler,Elizabeth A. Winzeler +11 more
TL;DR: A high-density oligonucleotide array is used to generate expression profiles of human and mosquito stages of the malaria parasite's life cycle and finds genes with highly correlated levels and temporal patterns of expression were often involved in similar functions or cellular processes.
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UHRF1 Plays a Role in Maintaining DNA Methylation in Mammalian Cells
Magnolia Bostick,Jong Kyong Kim,Pierre-Olivier Estève,Amander T. Clark,Sriharsa Pradhan,Steven E. Jacobsen +5 more
TL;DR: The data suggest that UHRF1 may help recruit DNMT1 to hemimethylated DNA to facilitate faithful maintenance of DNA methylation.
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Scaling Up Digital Circuit Computation with DNA Strand Displacement Cascades
Lulu Qian,Erik Winfree +1 more
TL;DR: This work experimentally demonstrated several digital logic circuits, culminating in a four-bit square-root circuit that comprises 130 DNA strands, which enables fast and reliable function in large circuits with roughly constant switching time and linear signal propagation delays.
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A common allele on chromosome 9 associated with coronary heart disease
Ruth McPherson,Alexander Pertsemlidis,Nihan Kavaslar,Alexandre F.R. Stewart,Robert Roberts,David R. Cox,David A. Hinds,Len A. Pennacchio,Anne Tybjærg-Hansen,Aaron R. Folsom,Eric Boerwinklle,Helen H. Hobbs,Jonathan Cohen +12 more
TL;DR: In this paper, a genome-wide associational study based on 100,000 single nucleotide polymorphisms and involving three sequential case-control comparisons made at a nominal significance threshold of P < 0.025 was conducted.
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