Open Access
疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
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TLDR
PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.Abstract:
抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。read more
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References
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Journal ArticleDOI
Sampling the Antibiotic Resistome
TL;DR: This work has shown that soil-dwelling bacteria are a reservoir of resistance determinants that can be mobilized into the microbial community, and study of this reservoir could provide an early warning system for future clinically relevant antibiotic resistance mechanisms.
Journal ArticleDOI
Superfamilies of evolved and designed networks.
Ron Milo,Shalev Itzkovitz,Nadav Kashtan,Reuven Levitt,Shai S. Shen-Orr,Inbal Ayzenshtat,Michal Sheffer,Uri Alon +7 more
TL;DR: An approach to systematically study similarity in the local structure of networks, based on the significance profile (SP) of small subgraphs in the network compared to randomized networks, finds several superfamilies of previously unrelated networks with very similar SPs.
Journal ArticleDOI
Spiropyran-based dynamic materials
TL;DR: This review discusses the synthesis, switching conditions, and use of dynamic materials in which spiropyran has been attached to the surfaces of polymers, biomacromolecules, inorganic nanoparticles, as well as solid surfaces.
Journal ArticleDOI
The status of the world's land and marine mammals: diversity, threat, and knowledge
Jan Schipper,Jan Schipper,Janice Chanson,Janice Chanson,Federica Chiozza,Neil A. Cox,Neil A. Cox,Michael R. Hoffmann,Michael R. Hoffmann,Vineet Katariya,John F. Lamoreux,John F. Lamoreux,Ana S. L. Rodrigues,Ana S. L. Rodrigues,Simon N. Stuart,Simon N. Stuart,Helen J. Temple,Jonathan E. M. Baillie,Luigi Boitani,Thomas E. Lacher,Thomas E. Lacher,Russell A. Mittermeier,Andrew T. Smith,Daniel Absolon,John M. Aguiar,John M. Aguiar,Giovanni Amori,Noura Bakkour,Noura Bakkour,Ricardo Baldi,Ricardo Baldi,Richard J. Berridge,Jon Bielby,Jon Bielby,Patricia Ann Black,Julian Blanc,Thomas M. Brooks,Thomas M. Brooks,Thomas M. Brooks,James Burton,James Burton,Thomas M. Butynski,Gianluca Catullo,Roselle Chapman,Zoe Cokeliss,Ben Collen,Jim Conroy,Justin Cooke,Gustavo A. B. da Fonseca,Gustavo A. B. da Fonseca,Andrew E. Derocher,Holly T. Dublin,J. W. Duckworth,Louise H. Emmons,Richard H. Emslie,Marco Festa-Bianchet,Matthew N. Foster,Sabrina Foster,David L. Garshelis,C. Cormack Gates,Mariano Gimenez-Dixon,Susana González,José F. González-Maya,Tatjana C. Good,Geoffrey Hammerson,Philip S. Hammond,D. C. D. Happold,Meredith Happold,John Hare,Richard B. Harris,Clare E. Hawkins,Clare E. Hawkins,Mandy Haywood,Lawrence R. Heaney,Simon Hedges,Kristofer M. Helgen,Craig Hilton-Taylor,Syed Ainul Hussain,Nobuo Ishii,Thomas Jefferson,Richard K. B. Jenkins,Charlotte H. Johnston,Mark Keith,Jonathan Kingdon,David Knox,Kit M. Kovacs,Kit M. Kovacs,Penny F. Langhammer,Kristin Leus,Rebecca L. Lewison,Gabriela Lichtenstein,Lloyd F. Lowry,Zoe Macavoy,Georgina M. Mace,David Mallon,Monica Masi,Meghan W. McKnight,Rodrigo A. Medellín,Patricia Medici,G. Mills,Patricia D. Moehlman,Sanjay Molur,Arturo Mora,Kristin Nowell,John F. Oates,Wanda Olech,William R.L. Oliver,Monik Oprea,Bruce D. Patterson,William F. Perrin,Beth Polidoro,Caroline M. Pollock,Abigail Powel,Yelizaveta Protas,Paul A. Racey,Jim Ragle,Pavithra Ramani,Galen B. Rathbun,Randall R. Reeves,Stephen B. Reilly,John E. Reynolds,Carlo Rondinini,Ruth Grace Rosell-Ambal,Monica Rulli,Anthony B. Rylands,Simona Savini,Cody J. Schank,Wes Sechrest,Caryn Self-Sullivan,Alan Shoemaker,Claudio Sillero-Zubiri,Naamal De Silva,David E. Smith,Chelmala Srinivasulu,P. J. Stephenson,Nico van Strien,Bibhab Kumar Talukdar,Barbara L. Taylor,Rob Timmins,Diego G. Tirira,Marcelo F. Tognelli,Marcelo F. Tognelli,Katerina Tsytsulina,Liza M. Veiga,Jean-Christophe Vié,Elizabeth A. Williamson,Sarah A. Wyatt,Yan Xie,Bruce E. Young +148 more
TL;DR: In this paper, the authors present a comprehensive assessment of the conservation status and distribution of the world's mammals, including marine mammals, using data collected by 1700+ experts, covering all 5487 species.
Journal ArticleDOI
Widespread Parallel Evolution in Sticklebacks by Repeated Fixation of Ectodysplasin Alleles
Pamela F. Colosimo,Kim E. Hosemann,Sarita Balabhadra,Guadalupe Villarreal,Mark Dickson,Jane Grimwood,Jeremy Schmutz,Richard M. Myers,Dolph Schluter,David M. Kingsley +9 more
TL;DR: The authors used positional cloning methods to identify the major chromosome locus controlling armor plate patterning in wild threespine sticklebacks and found that members of this clade of low-plated alleles are present at low frequencies in marine fish, which suggests that standing genetic variation can provide a molecular basis for rapid, parallel evolution of dramatic phenotypic change in nature.