Open Access
疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
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TLDR
PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.Abstract:
抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。read more
Citations
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Anterior cingulate conflict monitoring and adjustments in control
John G. Kerns,John G. Kerns,Jonathan D. Cohen,Jonathan D. Cohen,Angus W. MacDonald,Raymond Y. Cho,Raymond Y. Cho,V. Andrew Stenger,Cameron S. Carter,Cameron S. Carter +9 more
TL;DR: Using the Stroop color-naming task and controlling for repetition effects, it is demonstrated that ACC conflict-related activity predicts both greater prefrontal cortex activity and adjustments in behavior, supporting a role of ACC conflict monitoring in the engagement of cognitive control.
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The Role of the Medial Frontal Cortex in Cognitive Control.
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Switching from repression to activation: microRNAs can up-regulate translation.
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The Increasing Dominance of Teams in Production of Knowledge
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