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疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

宁北芳, +1 more
- Vol. 32, Iss: 04, pp 190-191
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TLDR
PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract
抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

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The status of the world's land and marine mammals: diversity, threat, and knowledge

Jan Schipper, +148 more
- 10 Oct 2008 - 
TL;DR: In this paper, the authors present a comprehensive assessment of the conservation status and distribution of the world's mammals, including marine mammals, using data collected by 1700+ experts, covering all 5487 species.
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Widespread Parallel Evolution in Sticklebacks by Repeated Fixation of Ectodysplasin Alleles

TL;DR: The authors used positional cloning methods to identify the major chromosome locus controlling armor plate patterning in wild threespine sticklebacks and found that members of this clade of low-plated alleles are present at low frequencies in marine fish, which suggests that standing genetic variation can provide a molecular basis for rapid, parallel evolution of dramatic phenotypic change in nature.
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Coding-sequence determinants of gene expression in Escherichia coli.

TL;DR: In this analysis, mRNA folding and associated rates of translation initiation play a predominant role in shaping expression levels of individual genes, whereas codon bias influences global translation efficiency and cellular fitness.
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