Open Access
疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
Reads0
Chats0
TLDR
PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.Abstract:
抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。read more
Citations
More filters
Journal ArticleDOI
Earth's Energy Imbalance: Confirmation and Implications
James Hansen,Larissa Nazarenko,Reto Ruedy,Makiko Sato,Josh K. Willis,Anthony D. Del Genio,Dorothy Koch,Andrew A. Lacis,Ken Lo,Surabi Menon,T. Novakov,Judith Perlwitz,Gary L. Russell,Gavin A. Schmidt,Nicholas Tausnev +14 more
TL;DR: It is calculated that Earth is now absorbing 0.85 ± 0.15 watts per square meter more energy from the Sun than it is emitting to space, confirmed by precise measurements of increasing ocean heat content over the past 10 years.
Journal ArticleDOI
Mutations in BRAF and KRAS Characterize the Development of Low-Grade Ovarian Serous Carcinoma
Gad Singer,Robert J. Oldt,Yoram Cohen,Brant G. Wang,David Sidransky,Robert J. Kurman,Ie Ming Shih +6 more
TL;DR: The apparent restriction of these BRAF and KRAS mutations to low-grade serous ovarian carcinoma and its precursors suggests that low- grade and high-grade ovarian serous carcinomas develop through independent pathways.
Journal ArticleDOI
Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine Protease
TL;DR: The NS3/4A protease represents a dual therapeutic target, the inhibition of which may both block viral replication and restore IRF-3 control of HCV infection.
Posted Content
Ink-Jet Printed Graphene Electronics
Felice Torrisi,Tawfique Hasan,W. Wu,Zhipei Sun,Antonio Lombardo,Tero S. Kulmala,G. W. Hshieh,S. J. Jung,Francesco Bonaccorso,P. J. Paul,Daping Chu,Andrea C. Ferrari +11 more
TL;DR: Inkjet printing is demonstrated as a viable method for large-area fabrication of graphene devices, and a graphene-based ink is produced by liquid phase exfoliation of graphite in N-methylpyrrolidone, paving the way to all-printed, flexible, and transparent graphene devices on arbitrary substrates.
Journal ArticleDOI
Functional and evolutionary insights from the genomes of three parasitoid Nasonia species.
John H. Werren,Stephen Richards,Christopher A. Desjardins,Oliver Niehuis,Jürgen Gadau,John K. Colbourne,Leo W. Beukeboom,Claude Desplan,Christine G. Elsik,Cornelis J. P. Grimmelikhuijzen,Paul Kitts,Jeremy A. Lynch,Terence Murphy,Deodoro C. S. G. Oliveira,Christopher D. Smith,Christopher D. Smith,Louis De Van Zande,Kim C. Worley,Evgeny M. Zdobnov,Maarten Aerts,Stefan Albert,Víctor Hugo Anaya,Juan Manuel Anzola,Angel Roberto Barchuk,Susanta K. Behura,Agata N. Bera,May R. Berenbaum,Rinaldo C. Bertossa,Márcia Maria Gentile Bitondi,Seth R. Bordenstein,Peer Bork,Erich Bornberg-Bauer,Marleen Brunain,Giuseppe Cazzamali,Lesley S. Chaboub,Joseph Chacko,Dean Chavez,Christopher P. Childers,Jeong Hyeon Choi,Michael E. Clark,Charles Claudianos,Rochelle A. Clinton,Andrew Cree,Alexandre S. Cristino,Alexandre S. Cristino,Phat M. Dang,Alistair C. Darby,Dirk C. de Graaf,Bart Devreese,Huyen Dinh,Rachel Edwards,Navin Elango,Eran Elhaik,Olga Ermolaeva,Jay D. Evans,Sylvain Forêt,Gerald R. Fowler,Daniel Gerlach,Joshua D. Gibson,Donald G. Gilbert,Dan Graur,Stefan Gründer,Darren E. Hagen,Yi Han,Frank Hauser,Da Hultmark,Henry C. Hunter,Gregory D. D. Hurst,Shalini N. Jhangian,Huaiyang Jiang,Reed M. Johnson,Andrew K. Jones,Thomas Junier,Tatsuhiko Kadowaki,A. Kamping,Yuri Kapustin,Bobak D. Kechavarzi,Jaebum Kim,Jay Kim,Boris Kiryutin,T. Koevoets,Christie Kovar,Evgenia V. Kriventseva,Robert Kucharski,Heewook Lee,Sandra L. Lee,Kristin Lees,Lora Lewis,David W. Loehlin,John M. Logsdon,Jacqueline Lopez,Ryan J. Lozado,Donna Maglott,Ryszard Maleszka,Anoop Mayampurath,Danielle J. Mazur,Marcella A. McClure,Andrew D. Moore,Margaret Morgan,Jean Muller,Monica Munoz-Torres,Donna M. Muzny,Lynne V. Nazareth,Susanne Neupert,Ngoc Nguyen,Francis M. F. Nunes,John G. Oakeshott,Geoffrey Okwuonu,Bart A. Pannebakker,Vikas Pejaver,Zuogang Peng,Stephen C. Pratt,Reinhard Predel,Ling Ling Pu,Hilary Ranson,Rhitoban Raychoudhury,Andreas Rechtsteiner,Andreas Rechtsteiner,Justin T. Reese,Jeffrey G. Reid,Megan Riddle,I. I. Hugh M Robertson,Jeanne Romero-Severson,Miriam I. Rosenberg,Timothy B. Sackton,David B. Sattelle,Helge Schlüns,Thomas Schmitt,Martina Schneider,Andreas Schüler,Andrew M. Schurko,David M. Shuker,Zilá Luz Paulino Simões,Saurabh Sinha,Zachary Smith,Victor V. Solovyev,Alexandre Souvorov,Andreas Springauf,Elisabeth Stafflinger,Deborah E. Stage,Deborah E. Stage,Mario Stanke,Yoshiaki Tanaka,Arndt Telschow,Carol Trent Selina Vattathil,I. I. Eveline C Verhulst,Lumi Viljakainen,Kevin W. Wanner,Robert M. Waterhouse,James B. Whitfield,Timothy E. Wilkes,Michael Williamson,Judith H. Willis,Florian Wolschin,Stefan Wyder,Stefan Wyder,Takuji Yamada,Soojin V. Yi,Courtney N. Zecher,Lan Zhang,Lan Zhang,Richard A. Gibbs +161 more
TL;DR: Key findings include the identification of a functional DNA methylation tool kit; hymenopteran-specific genes including diverse venoms; lateral gene transfers among Pox viruses, Wolbachia, and Nasonia; and the rapid evolution of genes involved in nuclear-mitochondrial interactions that are implicated in speciation.
References
More filters
Journal ArticleDOI
Raman spectrum of graphene and graphene layers.
Andrea C. Ferrari,Jannik C. Meyer,Vittorio Scardaci,Cinzia Casiraghi,Michele Lazzeri,Francesco Mauri,S. Piscanec,Da Jiang,K. S. Novoselov,S. Roth,A. K. Geim +10 more
TL;DR: This work shows that graphene's electronic structure is captured in its Raman spectrum that clearly evolves with the number of layers, and allows unambiguous, high-throughput, nondestructive identification of graphene layers, which is critically lacking in this emerging research area.
Journal ArticleDOI
Finding and evaluating community structure in networks.
TL;DR: It is demonstrated that the algorithms proposed are highly effective at discovering community structure in both computer-generated and real-world network data, and can be used to shed light on the sometimes dauntingly complex structure of networked systems.
Journal ArticleDOI
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
Martin Jinek,Krzysztof Chylinski,Krzysztof Chylinski,Ines Fonfara,Michael H. Hauer,Jennifer A. Doudna,Emmanuelle Charpentier +6 more
TL;DR: This study reveals a family of endonucleases that use dual-RNAs for site-specific DNA cleavage and highlights the potential to exploit the system for RNA-programmable genome editing.
Journal ArticleDOI
The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments
Stephen A. Bustin,Vladimir Benes,Jeremy A. Garson,Jan Hellemans,Jim F. Huggett,Mikael Kubista,Reinhold Mueller,Tania Nolan,Michael W. Pfaffl,Gregory L. Shipley,Jo Vandesompele,Carl T. Wittwer,Carl T. Wittwer +12 more
TL;DR: The Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines target the reliability of results to help ensure the integrity of the scientific literature, promote consistency between laboratories, and increase experimental transparency.
Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.