Open Access
疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
Reads0
Chats0
TLDR
PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.Abstract:
抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。read more
Citations
More filters
Journal ArticleDOI
Raman spectrum of graphene and graphene layers.
Andrea C. Ferrari,Jannik C. Meyer,Vittorio Scardaci,Cinzia Casiraghi,Michele Lazzeri,Francesco Mauri,S. Piscanec,Da Jiang,K. S. Novoselov,S. Roth,A. K. Geim +10 more
TL;DR: This work shows that graphene's electronic structure is captured in its Raman spectrum that clearly evolves with the number of layers, and allows unambiguous, high-throughput, nondestructive identification of graphene layers, which is critically lacking in this emerging research area.
Journal ArticleDOI
Finding and evaluating community structure in networks.
TL;DR: It is demonstrated that the algorithms proposed are highly effective at discovering community structure in both computer-generated and real-world network data, and can be used to shed light on the sometimes dauntingly complex structure of networked systems.
Journal ArticleDOI
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
Martin Jinek,Krzysztof Chylinski,Krzysztof Chylinski,Ines Fonfara,Michael H. Hauer,Jennifer A. Doudna,Emmanuelle Charpentier +6 more
TL;DR: This study reveals a family of endonucleases that use dual-RNAs for site-specific DNA cleavage and highlights the potential to exploit the system for RNA-programmable genome editing.
Journal ArticleDOI
The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments
Stephen A. Bustin,Vladimir Benes,Jeremy A. Garson,Jan Hellemans,Jim F. Huggett,Mikael Kubista,Reinhold Mueller,Tania Nolan,Michael W. Pfaffl,Gregory L. Shipley,Jo Vandesompele,Carl T. Wittwer,Carl T. Wittwer +12 more
TL;DR: The Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines target the reliability of results to help ensure the integrity of the scientific literature, promote consistency between laboratories, and increase experimental transparency.
Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
References
More filters
Journal ArticleDOI
ARGONAUTE4 Control of Locus-Specific siRNA Accumulation and DNA and Histone Methylation
TL;DR: The cloned ARGONAUTE4 (AGO4) was cloned from a screen for mutants that suppress silencing of the Arabidopsis SUPERMAN(SUP) gene and results suggest that AGO4 and long siRNAs direct chromatin modifications, including histone methylation and non-CpG DNA methylation.
Journal ArticleDOI
Efficient immunization strategies for computer networks and populations.
TL;DR: It is shown that the immunization threshold is dramatically reduced with the suggested strategy, for all studied cases, and analytically the critical threshold for complete immunization is studied.
Journal ArticleDOI
Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell
TL;DR: In a living Escherichia coli cell, specific binding of a lac repressor, labeled with a fluorescent protein, to a chromosomal lac operator is observed and the kinetics of binding and dissociation of the repressor in response to metabolic signals are measured using single-molecule detection techniques.
Journal ArticleDOI
World population stabilization unlikely this century
Patrick Gerland,Adrian E. Raftery,Hana Ševčíková,Nan Li,Danan Gu,Thomas Spoorenberg,Leontine Alkema,Bailey K. Fosdick,Jennifer Chunn,Nevena Lalic,Guiomar Bay,Thomas Buettner,Gerhard K. Heilig,John R. Wilmoth +13 more
TL;DR: World population is likely to continue growing for the rest of the century, with at least a 3.5-fold increase in the population of Africa and the ratio of working-age people to older people is almost certain to decline substantially in all countries, not just currently developed ones.
Journal ArticleDOI
Temperature-dependent transport in suspended graphene.
TL;DR: The resistivity of ultraclean suspended graphene is strongly temperature (T) dependent for 5