Open Access
疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
Reads0
Chats0
TLDR
PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.Abstract:
抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。read more
Citations
More filters
Journal ArticleDOI
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
TL;DR: Multifaceted technologies are increasingly required to produce and interrogate cells ex vivo, to build predictive models, and, ultimately, to enhance stem cell integration in vivo for therapeutic benefit.
Journal ArticleDOI
Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences
Junying Yu,Junying Yu,Kejin Hu,Kim Smuga-Otto,Kim Smuga-Otto,Shulan Tian,Shulan Tian,Ron Stewart,Ron Stewart,Igor I. Slukvin,James A. Thomson +10 more
TL;DR: Results demonstrate that reprograming human somatic cells does not require genomic integration or the continued presence of exogenous reprogramming factors and removes one obstacle to the clinical application of human iPS cells.
Journal ArticleDOI
A Protein Interaction Map of Drosophila melanogaster
Loic Giot,Joel S. Bader,Cory Brouwer,Amitabha Chaudhuri,B. Kuang,Ying Li,Y. L. Hao,C. E. Ooi,Brian C. Godwin,E. Vitols,G. Vijayadamodar,Pascale Pochart,H. Machineni,M. Welsh,Yong Kong,B. Zerhusen,Rachel D. Malcolm,Z. Varrone,A. Collis,M. Minto,S. Burgess,L. McDaniel,E. Stimpson,F. Spriggs,Julia Williams,K. Neurath,N. Ioime,M. Agee,E. Voss,K. Furtak,R. Renzulli,N. Aanensen,S. Carrolla,E. Bickelhaupt,Y. Lazovatsky,A. DaSilva,Jinhui Zhong,Clement A. Stanyon,Russell L. Finley,Kevin P. White,Michael S. Braverman,Thomas P. Jarvie,Steven Allen Gold,M. Leach,James R. Knight,Richard A. Shimkets,Michael P. McKenna,John Chant,Jonathan M. Rothberg +48 more
TL;DR: This map serves as a starting point for a systems biology modeling of multicellular organisms, including humans, and recapitulated known pathways, extended pathways, and uncovered previously unknown pathway components.
Journal ArticleDOI
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
W. James Nelson,Roel Nusse +1 more
TL;DR: Evidence is assembled of possible interrelations between Wnt and other growth factor signaling, β-catenin functions, and cadherin-mediated adhesion in tissue differentiation.
Journal ArticleDOI
Quantum dynamics of single trapped ions
TL;DR: Theoretical and experimental work on radio-frequency (Paul) traps is reviewed in this paper, with a focus on ions trapped in radiofrequency traps, which are ideal for quantum-optical and quantum-dynamical studies under well controlled conditions.
References
More filters
Journal ArticleDOI
Raman spectrum of graphene and graphene layers.
Andrea C. Ferrari,Jannik C. Meyer,Vittorio Scardaci,Cinzia Casiraghi,Michele Lazzeri,Francesco Mauri,S. Piscanec,Da Jiang,K. S. Novoselov,S. Roth,A. K. Geim +10 more
TL;DR: This work shows that graphene's electronic structure is captured in its Raman spectrum that clearly evolves with the number of layers, and allows unambiguous, high-throughput, nondestructive identification of graphene layers, which is critically lacking in this emerging research area.
Journal ArticleDOI
Finding and evaluating community structure in networks.
TL;DR: It is demonstrated that the algorithms proposed are highly effective at discovering community structure in both computer-generated and real-world network data, and can be used to shed light on the sometimes dauntingly complex structure of networked systems.
Journal ArticleDOI
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
Martin Jinek,Krzysztof Chylinski,Krzysztof Chylinski,Ines Fonfara,Michael H. Hauer,Jennifer A. Doudna,Emmanuelle Charpentier +6 more
TL;DR: This study reveals a family of endonucleases that use dual-RNAs for site-specific DNA cleavage and highlights the potential to exploit the system for RNA-programmable genome editing.
Journal ArticleDOI
The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments
Stephen A. Bustin,Vladimir Benes,Jeremy A. Garson,Jan Hellemans,Jim F. Huggett,Mikael Kubista,Reinhold Mueller,Tania Nolan,Michael W. Pfaffl,Gregory L. Shipley,Jo Vandesompele,Carl T. Wittwer,Carl T. Wittwer +12 more
TL;DR: The Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines target the reliability of results to help ensure the integrity of the scientific literature, promote consistency between laboratories, and increase experimental transparency.
Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.