Open Access
疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
Reads0
Chats0
TLDR
PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.Abstract:
抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。read more
Citations
More filters
Journal ArticleDOI
Raman spectrum of graphene and graphene layers.
Andrea C. Ferrari,Jannik C. Meyer,Vittorio Scardaci,Cinzia Casiraghi,Michele Lazzeri,Francesco Mauri,S. Piscanec,Da Jiang,K. S. Novoselov,S. Roth,A. K. Geim +10 more
TL;DR: This work shows that graphene's electronic structure is captured in its Raman spectrum that clearly evolves with the number of layers, and allows unambiguous, high-throughput, nondestructive identification of graphene layers, which is critically lacking in this emerging research area.
Journal ArticleDOI
Finding and evaluating community structure in networks.
TL;DR: It is demonstrated that the algorithms proposed are highly effective at discovering community structure in both computer-generated and real-world network data, and can be used to shed light on the sometimes dauntingly complex structure of networked systems.
Journal ArticleDOI
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
Martin Jinek,Krzysztof Chylinski,Krzysztof Chylinski,Ines Fonfara,Michael H. Hauer,Jennifer A. Doudna,Emmanuelle Charpentier +6 more
TL;DR: This study reveals a family of endonucleases that use dual-RNAs for site-specific DNA cleavage and highlights the potential to exploit the system for RNA-programmable genome editing.
Journal ArticleDOI
The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments
Stephen A. Bustin,Vladimir Benes,Jeremy A. Garson,Jan Hellemans,Jim F. Huggett,Mikael Kubista,Reinhold Mueller,Tania Nolan,Michael W. Pfaffl,Gregory L. Shipley,Jo Vandesompele,Carl T. Wittwer,Carl T. Wittwer +12 more
TL;DR: The Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines target the reliability of results to help ensure the integrity of the scientific literature, promote consistency between laboratories, and increase experimental transparency.
Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
References
More filters
Journal ArticleDOI
Assembly of micro/nanomaterials into complex, three-dimensional architectures by compressive buckling
Sheng Xu,Zheng Yan,Kyung In Jang,Wen Huang,Fu Haoran,Fu Haoran,Jeonghyun Kim,Jeonghyun Kim,Zijun Wei,Matthew T. Flavin,Joselle M. McCracken,Renhan Wang,Adina Badea,Yuhao Liu,Dongqing Xiao,Guoyan Zhou,Guoyan Zhou,Jung Woo Lee,Jung Woo Lee,Ha Uk Chung,Huanyu Cheng,Huanyu Cheng,Wen Ren,Anthony Banks,Xiuling Li,Ungyu Paik,Ralph G. Nuzzo,Yonggang Huang,Yihui Zhang,Yihui Zhang,John A. Rogers +30 more
TL;DR: An ingenious design strategy for the microfabrication of complex geometric 3D mesostructures that derive from the out-of-plane buckling of an originally planar structural layout is developed.
Journal ArticleDOI
Application of metal coordination chemistry to explore and manipulate cell biology.
TL;DR: Inorganic compounds should not be overlooked in the realm of chemical biology, since their distinctive electronic, chemical, and photophysical properties render them particularly useful for a variety of applications.
Journal ArticleDOI
Screening of Protein Crystallization Conditions on a Microfluidic Chip Using Nanoliter-Size Droplets
TL;DR: A microfluidic system for screening hundreds of protein crystallization conditions using less than 4 nL of protein solution for each crystallization droplet is described, validated by crystallization of several water-soluble proteins.
Journal ArticleDOI
Direct Experimental Evidence of a Growing Length Scale Accompanying the Glass Transition
Ludovic Berthier,Giulio Biroli,Jean-Philippe Bouchaud,Luca Cipelletti,D. El Masri,D. L’Hôte,François Ladieu,Matteo Pierno +7 more
TL;DR: New multipoint dynamical susceptibilities are introduced to estimate quantitatively the size of these regions and provide direct experimental evidence that the glass formation of molecular liquids and colloidal suspensions is accompanied by growing dynamic correlation length scales.
Journal ArticleDOI
The Late Pleistocene Dispersal of Modern Humans in the Americas
Ted Goebel,Ted Goebel,Michael R. Waters,Michael R. Waters,Dennis H. O'Rourke,Dennis H. O'Rourke +5 more
TL;DR: Current genetic evidence implies dispersal from a single Siberian population toward the Bering Land Bridge no earlier than about 30,000 years ago, then migration from Beringia to the Americas sometime after 16,500 years ago.