Open Access
疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
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TLDR
PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.Abstract:
抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。read more
Citations
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Protein Phylogenetic Analysis of Ca2+/cation Antiporters and Insights into their Evolution in Plants
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Frequency Comparison of Two High-Accuracy Al+ Optical Clocks
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The Neural Architecture of the Language Comprehension Network: Converging Evidence from Lesion and Connectivity Analyses
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Androgen Deprivation Therapy for Prostate Cancer
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Functional Amyloids as Natural Storage of Peptide Hormones in Pituitary Secretory Granules
Samir K. Maji,Marilyn H. Perrin,Michael R. Sawaya,Sebastian Jessberger,Krishna C. Vadodaria,Robert A. Rissman,Praful S. Singru,K. Peter R. Nilsson,Rozalyn Simon,David Schubert,David Eisenberg,Jean Rivier,Paul E. Sawchenko,Wylie Vale,Roland Riek,Roland Riek +15 more
TL;DR: It is found that peptide and protein hormones in secretory granules of the endocrine system are stored in an amyloid-like cross–β-sheet–rich conformation, which means functional amyloids in the pituitary and other organs can contribute to normal cell and tissue physiology.
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