Open Access
疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
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TLDR
PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.Abstract:
抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。read more
Citations
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A Catalog of Reference Genomes from the Human Microbiome
Karen E. Nelson,George M. Weinstock,Sarah K. Highlander,Kim C. Worley,Heather Huot Creasy,Jennifer R. Wortman,Douglas B. Rusch,Makedonka Mitreva,Erica Sodergren,Asif T. Chinwalla,Michael Feldgarden,Dirk Gevers,Brian J. Haas,Ramana Madupu,Doyle V. Ward,Bruce W. Birren,Richard A. Gibbs,Barbara A. Methé,Joseph F. Petrosino,Robert L. Strausberg,Granger G. Sutton,Owen White,Richard K. Wilson,Scott Durkin,Michelle G. Giglio,Sharvari Gujja,Clint Howarth,Chinnappa D. Kodira,Nikos C. Kyrpides,Teena Mehta,Donna M. Muzny,Matthew D. Pearson,Kymberlie H. Pepin,Amrita Pati,Xiang Qin,Chandri N. Yandava,Qiandong Zeng,Lan Zhang,Aaron M. Berlin,Lei Chen,Theresa A. Hepburn,Justin Johnson,Jamison McCorrison,Jason R. Miller,Patrick Minx,Chad Nusbaum,Carsten Russ,Sean M. Sykes,Chad Tomlinson,Sarah Young,Wesley C. Warren,Jonathan H. Badger,Jonathan Crabtree,Victor Markowitz,Joshua Orvis,Andrew Cree,Steve Ferriera,Lucinda Fulton,Robert S. Fulton,Marcus Gillis,Lisa Hemphill,Vandita Joshi,Christie Kovar,Manolito Torralba,Kris A. Wetterstrand,Amr Abouellleil,Aye Wollam,Christian J. Buhay,Yan Ding,Shannon Dugan,Michael Fitzgerald,Mike Holder,Jessica B. Hostetler,Sandra W. Clifton,Emma Allen-Vercoe,Ashlee M. Earl,Candace N. Farmer,Konstantinos Liolios,Michael G. Surette,Qiang Xu,Craig Pohl,Katarzyna Wilczek-Boney,Dianhui Zhu +82 more
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