Open Access
疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
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TLDR
PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.Abstract:
抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。read more
Citations
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Caspases 3 and 7: key mediators of mitochondrial events of apoptosis.
Saquib A. Lakhani,Ali Masud,Keisuke Kuida,George A. Porter,Carmen J. Booth,Wajahat Z. Mehal,Irteza Inayat,Richard A. Flavell +7 more
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Analysis of genetic inheritance in a family quartet by whole-genome sequencing
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TL;DR: Family-based genome analysis enabled us to narrow the candidate genes for both of these Mendelian disorders to only four and demonstrate the value of complete genome sequencing in families.
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