Open Access
疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
Reads0
Chats0
TLDR
PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.Abstract:
抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。read more
Citations
More filters
Journal ArticleDOI
The Application of Ecological Theory Toward an Understanding of the Human Microbiome
Elizabeth K. Costello,Keaton Stagaman,Les Dethlefsen,Brendan J. M. Bohannan,David A. Relman,David A. Relman +5 more
TL;DR: This work explores three core scenarios of human microbiome assembly: development in infants, representing assembly in previously unoccupied habitats; recovery from antibiotics, representingassembly after disturbance; and invasion by pathogens, representingAssembly in the context of invasive species.
Journal ArticleDOI
Inferring genetic networks and identifying compound mode of action via expression profiling
TL;DR: Systematic transcriptional perturbations are used to construct a first-order model of regulatory interactions in a nine-gene subnetwork of the SOS pathway in Escherichia coli that provides a framework for elucidating the functional properties of genetic networks and identifying molecular targets of pharmacological compounds.
Journal ArticleDOI
Aptamer-based biosensors
TL;DR: Recent advances in the development of aptamer-based biosensors and bioassay methods, most of which have employed electrochemical, optical and mass-sensitive analytical techniques are summarized.
Journal ArticleDOI
A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes
Daniel G. MacArthur,Daniel G. MacArthur,Suganthi Balasubramanian,Adam Frankish,Ni Huang,James Morris,Klaudia Walter,Luke Jostins,Lukas Habegger,Joseph K. Pickrell,Stephen B. Montgomery,Stephen B. Montgomery,Cornelis A. Albers,Cornelis A. Albers,Zhengdong D. Zhang,Donald F. Conrad,Gerton Lunter,Hancheng Zheng,Qasim Ayub,Mark A. DePristo,Eric Banks,Min Hu,Robert E. Handsaker,Robert E. Handsaker,Jeffrey A. Rosenfeld,Menachem Fromer,Mike Jin,Xinmeng Jasmine Mu,Ekta Khurana,Kai Ye,M. Kay,Gary Saunders,Marie-Marthe Suner,Toby Hunt,If H. A. Barnes,Clara Amid,Denise Carvalho-Silva,Alexandra Bignell,Catherine E. Snow,Bryndis Yngvadottir,Suzannah Bumpstead,David Neil Cooper,Yali Xue,Irene Gallego Romero,Irene Gallego Romero,Jun Wang,Yingrui Li,Richard A. Gibbs,Steven A. McCarroll,Steven A. McCarroll,Emmanouil T. Dermitzakis,Jonathan K. Pritchard,Jeffrey C. Barrett,Jennifer Harrow,Matthew E. Hurles,Mark Gerstein,Chris Tyler-Smith +56 more
TL;DR: Functional and evolutionary differences between LoF-tolerant and recessive disease genes and a method for using these differences to prioritize candidate genes found in clinical sequencing studies are described.
Journal ArticleDOI
Collapse and Conservation of Shark Populations in the Northwest Atlantic
Julia K. Baum,Ransom A. Myers,Daniel G. Kehler,Boris Worm,Shelton J. Harley,Penny A. Doherty +5 more
TL;DR: Open-area models highlight priority areas for shark conservation, and the need to consider effort reallocation and site selection if marine reserves are to benefit multiple threatened species.
References
More filters
Journal ArticleDOI
Raman spectrum of graphene and graphene layers.
Andrea C. Ferrari,Jannik C. Meyer,Vittorio Scardaci,Cinzia Casiraghi,Michele Lazzeri,Francesco Mauri,S. Piscanec,Da Jiang,K. S. Novoselov,S. Roth,A. K. Geim +10 more
TL;DR: This work shows that graphene's electronic structure is captured in its Raman spectrum that clearly evolves with the number of layers, and allows unambiguous, high-throughput, nondestructive identification of graphene layers, which is critically lacking in this emerging research area.
Journal ArticleDOI
Finding and evaluating community structure in networks.
TL;DR: It is demonstrated that the algorithms proposed are highly effective at discovering community structure in both computer-generated and real-world network data, and can be used to shed light on the sometimes dauntingly complex structure of networked systems.
Journal ArticleDOI
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
Martin Jinek,Krzysztof Chylinski,Krzysztof Chylinski,Ines Fonfara,Michael H. Hauer,Jennifer A. Doudna,Emmanuelle Charpentier +6 more
TL;DR: This study reveals a family of endonucleases that use dual-RNAs for site-specific DNA cleavage and highlights the potential to exploit the system for RNA-programmable genome editing.
Journal ArticleDOI
The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments
Stephen A. Bustin,Vladimir Benes,Jeremy A. Garson,Jan Hellemans,Jim F. Huggett,Mikael Kubista,Reinhold Mueller,Tania Nolan,Michael W. Pfaffl,Gregory L. Shipley,Jo Vandesompele,Carl T. Wittwer,Carl T. Wittwer +12 more
TL;DR: The Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines target the reliability of results to help ensure the integrity of the scientific literature, promote consistency between laboratories, and increase experimental transparency.
Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.