Open Access
疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
Reads0
Chats0
TLDR
PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.Abstract:
抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。read more
Citations
More filters
Journal ArticleDOI
Global Assessment of Organic Contaminants in Farmed Salmon
Ronald A. Hites,Jeffery A. Foran,David O. Carpenter,M. Coreen Hamilton,Barbara A. Knuth,Steven J. Schwager +5 more
TL;DR: It is shown that concentrations of these contaminants are significantly higher in farmed salmon than in wild, and consumption of farmed Atlantic salmon may pose health risks that detract from the beneficial effects of fish consumption.
Journal ArticleDOI
Finding functional features in Saccharomyces genomes by phylogenetic footprinting.
Paul F. Cliften,Priya Sudarsanam,Ashwin Desikan,Lucinda Fulton,Bob Fulton,John Majors,Robert H. Waterston,Barak A. Cohen,Mark Johnston +8 more
TL;DR: Comparison of genome sequences of six Saccharomyces species allowed us to revise the catalog of yeast genes and identify sequence motifs that may be targets of transcriptional regulatory proteins.
Journal ArticleDOI
Toward high-resolution de novo structure prediction for small proteins.
TL;DR: The prediction of protein structure from amino acid sequence is a grand challenge of computational molecular biology and the primary bottleneck to consistent high-resolution prediction appears to be conformational sampling.
Journal ArticleDOI
Detection, Stimulation, and Inhibition of Neuronal Signals with High-Density Nanowire Transistor Arrays
Fernando Patolsky,Brian P. Timko,Guihua Yu,Ying Fang,Andrew B. Greytak,Gengfeng Zheng,Charles M. Lieber +6 more
TL;DR: Electrical properties of hybrid structures consisting of arrays of nanowire field-effect transistors integrated with the individual axons and dendrites of live mammalian neurons, where each nanoscale junction can be used for spatially resolved, highly sensitive detection, stimulation, and/or inhibition of neuronal signal propagation are reported.
Journal ArticleDOI
A test of climate, sun, and culture relationships from an 1810-year Chinese cave record.
Pingzhong Zhang,Hai Cheng,R. Lawrence Edwards,Fahu Chen,Yongjin Wang,Xunlin Yang,Jian Liu,Ming Tan,Xianfeng Wang,Jinghua Liu,Chunlei An,Zhibo Dai,Jing Zhou,Dezhong Zhang,Jihong Jia,Liya Jin,Kathleen R. Johnson +16 more
TL;DR: The sign of the correlation between the AM and temperature switches around 1960 is suggested, suggesting that anthropogenic forcing superseded natural forcing as the major driver of AM changes in the late 20th century.
References
More filters
Journal ArticleDOI
Raman spectrum of graphene and graphene layers.
Andrea C. Ferrari,Jannik C. Meyer,Vittorio Scardaci,Cinzia Casiraghi,Michele Lazzeri,Francesco Mauri,S. Piscanec,Da Jiang,K. S. Novoselov,S. Roth,A. K. Geim +10 more
TL;DR: This work shows that graphene's electronic structure is captured in its Raman spectrum that clearly evolves with the number of layers, and allows unambiguous, high-throughput, nondestructive identification of graphene layers, which is critically lacking in this emerging research area.
Journal ArticleDOI
Finding and evaluating community structure in networks.
TL;DR: It is demonstrated that the algorithms proposed are highly effective at discovering community structure in both computer-generated and real-world network data, and can be used to shed light on the sometimes dauntingly complex structure of networked systems.
Journal ArticleDOI
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
Martin Jinek,Krzysztof Chylinski,Krzysztof Chylinski,Ines Fonfara,Michael H. Hauer,Jennifer A. Doudna,Emmanuelle Charpentier +6 more
TL;DR: This study reveals a family of endonucleases that use dual-RNAs for site-specific DNA cleavage and highlights the potential to exploit the system for RNA-programmable genome editing.
Journal ArticleDOI
The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments
Stephen A. Bustin,Vladimir Benes,Jeremy A. Garson,Jan Hellemans,Jim F. Huggett,Mikael Kubista,Reinhold Mueller,Tania Nolan,Michael W. Pfaffl,Gregory L. Shipley,Jo Vandesompele,Carl T. Wittwer,Carl T. Wittwer +12 more
TL;DR: The Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines target the reliability of results to help ensure the integrity of the scientific literature, promote consistency between laboratories, and increase experimental transparency.
Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.