Open Access
疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
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TLDR
PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.Abstract:
抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。read more
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References
More filters
Journal ArticleDOI
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa.
Andreas Villunger,Andreas Villunger,Ewa M. Michalak,Leigh Coultas,Franziska Müllauer,Günther Böck,Michael J. Ausserlechner,Jerry M. Adams,Andreas Strasser +8 more
TL;DR: In mice with either noxa or puma disrupted, decreased DNA damage–induced apoptosis in fibroblasts is observed, although only loss of Puma protected lymphocytes from cell death, and Puma deficiency protected cells against diverse p53-independent cytotoxic insults.
Journal ArticleDOI
TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation
TL;DR: Recent advances in molecular and genetic studies using gene targeting in mice enable a better understanding of TGF-β/BMP signaling in bone and in the signaling networks underlying osteoblast differentiation and bone formation.
Journal ArticleDOI
Stable prenucleation calcium carbonate clusters.
TL;DR: It is demonstrated that dissolved calcium carbonate in fact contains stable prenucleation ion clusters forming even in undersaturated solution, and specified complex crystal structures challenge the classical view on nucleation considering the formation of metastable ion clusters.
Journal ArticleDOI
Nanofocusing of Optical Energy in Tapered Plasmonic Waveguides
TL;DR: It is predicted theoretically that surface plAsmon polaritons propagating toward the tip of a tapered plasmonic waveguide are slowed down and asymptotically stopped when they tend to the tip, never actually reaching it (the travel time to the Tip is logarithmically divergent).
Journal ArticleDOI
Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies
Ujwal Sheth,Roy Parker +1 more
TL;DR: The flux of mRNAs between polysomes and P bodies is defined as a critical aspect of cytoplasmic mRNA metabolism and a possible site for regulation of mRNA degradation.