Open Access
疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
Reads0
Chats0
TLDR
PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.Abstract:
抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。read more
Citations
More filters
Journal ArticleDOI
Transfer of Learning After Updating Training Mediated by the Striatum
TL;DR: Findings indicate that transfer can occur if the criterion and transfer tasks engage specific overlapping processing components and brain regions.
Journal ArticleDOI
Self-Assembly of CdTe Nanocrystals into Free-Floating Sheets
TL;DR: Computer simulation and concurrent experiments demonstrated that the dipole moment, small positive charge, and directional hydrophobic attraction are the driving forces for the self-organization process of CdTe nanoparticles.
Journal ArticleDOI
AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides
Oscar Conchillo-Solé,Natalia Sanchez de Groot,Francesc X. Avilés,Josep Vendrell,Xavier Daura,Xavier Daura,Salvador Ventura +6 more
TL;DR: The algorithm is shown to identify a series of protein fragments involved in the aggregation of disease-related proteins and to predict the effect of genetic mutations on their deposition propensities, which shall facilitate the identification of possible therapeutic targets for anti-depositional strategies in conformational diseases.
Journal ArticleDOI
Vertex similarity in networks
TL;DR: A measure of similarity based on the concept that two vertices are similar if their immediate neighbors in the network are themselves similar is proposed, which leads to a self-consistent matrix formulation of similarity that can be evaluated iteratively using only a knowledge of the adjacency matrix of the network.
Journal ArticleDOI
A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity
Daniel Cifuentes,Huiling Xue,David W. Taylor,Heather Patnode,Yuichiro Mishima,Yuichiro Mishima,Sihem Cheloufi,Sihem Cheloufi,E. Ma,Shrikant Mane,Gregory J. Hannon,Nathan D. Lawson,Scot A. Wolfe,Antonio J. Giraldez +13 more
TL;DR: It is proposed that Ago2-mediated cleavage of pre-miRNAs, followed by uridylation and trimming, generates functional miRNAs independently of Dicer, which suggests that other mi RNAs might also be processed in this way.
References
More filters
Journal ArticleDOI
Raman spectrum of graphene and graphene layers.
Andrea C. Ferrari,Jannik C. Meyer,Vittorio Scardaci,Cinzia Casiraghi,Michele Lazzeri,Francesco Mauri,S. Piscanec,Da Jiang,K. S. Novoselov,S. Roth,A. K. Geim +10 more
TL;DR: This work shows that graphene's electronic structure is captured in its Raman spectrum that clearly evolves with the number of layers, and allows unambiguous, high-throughput, nondestructive identification of graphene layers, which is critically lacking in this emerging research area.
Journal ArticleDOI
Finding and evaluating community structure in networks.
TL;DR: It is demonstrated that the algorithms proposed are highly effective at discovering community structure in both computer-generated and real-world network data, and can be used to shed light on the sometimes dauntingly complex structure of networked systems.
Journal ArticleDOI
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
Martin Jinek,Krzysztof Chylinski,Krzysztof Chylinski,Ines Fonfara,Michael H. Hauer,Jennifer A. Doudna,Emmanuelle Charpentier +6 more
TL;DR: This study reveals a family of endonucleases that use dual-RNAs for site-specific DNA cleavage and highlights the potential to exploit the system for RNA-programmable genome editing.
Journal ArticleDOI
The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments
Stephen A. Bustin,Vladimir Benes,Jeremy A. Garson,Jan Hellemans,Jim F. Huggett,Mikael Kubista,Reinhold Mueller,Tania Nolan,Michael W. Pfaffl,Gregory L. Shipley,Jo Vandesompele,Carl T. Wittwer,Carl T. Wittwer +12 more
TL;DR: The Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines target the reliability of results to help ensure the integrity of the scientific literature, promote consistency between laboratories, and increase experimental transparency.
Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.