Open Access
疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
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TLDR
PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.Abstract:
抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。read more
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References
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Journal ArticleDOI
The Protein-Folding Problem, 50 Years On
Ken A. Dill,Justin L. MacCallum +1 more
TL;DR: Progress is reviewed on three broad questions: What is the physical code by which an amino acid sequence dictates a protein’s native structure?
Journal ArticleDOI
SELEX--a (r)evolutionary method to generate high-affinity nucleic acid ligands.
TL;DR: The SELEX method was modified over the years to become more efficient and less time consuming, to reach higher affinities of the aptamers selected and for automation of the process.
Journal ArticleDOI
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
Zhe-Yu Chen,Deqiang Jing,Kevin G. Bath,Alessandro Ieraci,Tanvir Khan,Chia-Jen Siao,Daniel G. Herrera,Miklós Tóth,Chingwen Yang,Bruce S. McEwen,Barbara L. Hempstead,Francis S. Lee +11 more
TL;DR: A variant BDNF mouse (BDNFMet/Met) is generated that reproduces the phenotypic hallmarks in humans with the variant allele and may play a key role in genetic predispositions to anxiety and depressive disorders.
Journal ArticleDOI
Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy
Petr Klán,Tomáš Šolomek,Christian G. Bochet,Aurélien Blanc,Richard S. Givens,Marina Rubina,Vladimir V. Popik,Alexey Kostikov,Jakob Wirz +8 more
TL;DR: The review covers the knowledge on photoremovable protecting groups and includes all relevant chromophores studied in the time period of 2000–2012 and the most relevant earlier works are discussed.
Journal ArticleDOI
RNAi-Mediated Targeting of Heterochromatin by the RITS Complex
André Verdel,Songtao Jia,Scott A. Gerber,Tomoyasu Sugiyama,Steven P. Gygi,Shiv I. S. Grewal,Danesh Moazed +6 more
TL;DR: The purification of an RNAi effector complex termed RITS (RNA-induced initiation of transcriptional gene silencing) that is required for heterochromatin assembly in fission yeast is described and a mechanism for the role of the RNAi machinery and small RNAs in targeting of heterochROMatin complexes and epigenetic genesilencing at specific chromosomal loci is suggested.