Journal ArticleDOI
The evolution of signalling pathways in animal development
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Looking at how these pathways evolved might provide insights into how a few signalling pathways can generate so much cellular and morphological diversity during the development of individual organisms and the evolution of animal body plans.Abstract:
Despite the bewildering number of cell types and patterns found in the animal kingdom, only a few signalling pathways are required to generate them. Most cell‐cell interactions during embryonic development involve the Hedgehog, Wnt, transforming growth factor-β, receptor tyrosine kinase, Notch, JAK/STAT and nuclear hormone pathways. Looking at how these pathways evolved might provide insights into how a few signalling pathways can generate so much cellular and morphological diversity during the development of individual organisms and the evolution of animal body plans.read more
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Proceedings Article
Biological robustness
Hiroaki Kitano,F. Matsuno +1 more
TL;DR: Insights into inherent properties of robust systems will provide a better understanding of complex diseases and a guiding principle for therapy design.
Journal ArticleDOI
Insights into social insects from the genome of the honeybee Apis mellifera
George M. Weinstock,Gene E. Robinson,Richard A. Gibbs,Kim C. Worley,Jay D. Evans,Ryszard Maleszka,Hugh M. Robertson,Daniel B. Weaver,Martin Beye,Peer Bork,Christine G. Elsik,Klaus Hartfelder,Greg J. Hunt,Evgeny M. Zdobnov,Gro V. Amdam,Mrcia M.G. Bitondi,Anita M. Collins,Alexandre S. Cristino,H. Michael G. Lattorff,Carlos H. Lobo,Robin F. A. Moritz,Francis M. F. Nunes,Robert E. Page,Zilá Luz Paulino Simões,Diana E. Wheeler,Piero Carninci,Shiro Fukuda,Yoshihide Hayashizaki,Chikatoshi Kai,Jun Kawai,Naoko Sakazume,Daisuke Sasaki,Michihira Tagami,Stefan Albert,Geert Baggerman,Kyle T. Beggs,Guy Bloch,Giuseppe Cazzamali,Mira Cohen,Mark D. Drapeau,Dorothea Eisenhardt,Christine Emore,Michael A. Ewing,Susan E. Fahrbach,Sylvain Forêt,Cornelis J. P. Grimmelikhuijzen,Frank Hauser,Amanda B. Hummon,Jurgen Huybrechts,Andrew K. Jones,Tatsuhiko Kadowaki,Noam Kaplan,Robert Kucharski,Grard Leboulle,Michal Linial,J. Troy Littleton,Alison R. Mercer,T.A. Richmond,Sandra L. Rodriguez-Zas,Elad B. Rubin,David B. Sattelle,David I. Schlipalius,Liliane Schoofs,Yair Shemesh,Jonathan V. Sweedler,Rodrigo A. Velarde,Peter Verleyen,Evy Vierstraete,Michael Williamson,Seth A. Ament,Susan J. Brown,Miguel Corona,Peter K. Dearden,W. Augustine Dunn,Michelle M. Elekonich,Tomoko Fujiyuki,Irene Gattermeier,Tanja Gempe,Martin Hasselmann,Eriko Kage,Azusa Kamikouchi,Takeo Kubo,Takekazu Kunieda,Marcé D. Lorenzen,Natalia V. Milshina,Mizue Morioka,Kazuaki Ohashi,Ross Overbeek,Christian A. Ross,Morten Schioett,Teresa D. Shippy,Hideaki Takeuchi,Amy L. Toth,Judith H. Willis,Megan J. Wilson,Karl H.J. Gordon,Ivica Letunic,Kevin J. Hackett,Jane Peterson,Adam Felsenfeld,Mark S. Guyer,Michel Solignac,Richa Agarwala,Jean Marie Cornuet,M. Monnerot,Florence Mougel,Justin T. Reese,Dominique Vautrin,Joseph J. Gillespie,Joseph J. Gillespie,Jamie J. Cannone,Robin R. Gutell,J. Spencer Johnston,Michael B. Eisen,Michael B. Eisen,Venky N. Iyer,Vivek Iyer,Peter Kosarev,Aaron J. Mackey,Victor V. Solovyev,Alexandre Souvorov,Katherine A Aronstein,Katarína Bíliková,Yanping Chen,Andrew G. Clark,Laura I. Decanini,William M. Gelbart,Charles Hetru,Dan Hultmark,Jean-Luc Imler,Haobo Jiang,Michael R. Kanost,Kiyoshi Kimura,Brian P. Lazzaro,Dawn Lopez,Jozef Šimúth,Graham J. Thompson,Zhen Zou,Pieter J. de Jong,Erica Sodergren,Miklós Csürös,Aleksandar Milosavljevic,Kazutoyo Osoegawa,Stephen Richards,Chung Li Shu,Laurent Duret,Eran Elhaik,Dan Graur,Juan Manuel Anzola,Kathryn S. Campbell,Kevin L. Childs,Derek Collinge,Madeline A. Crosby,C. Michael Dickens,L. Sian Grametes,Christina M. Grozinger,Peter L. Jones,Mireia Jordà,Xu Ling,Beverly B. Matthews,Jonathan Miller,Craig Mizzen,Miguel A. Peinado,Jeffrey G. Reid,Jeffrey G. Reid,Susan M. Russo,Andrew J. Schroeder,Susan E. St. Pierre,Ying Wang,Pinglei Zhou,Huaiyang Jiang,Paul Kitts,Barbara J. Ruef,Anand Venkatraman,Lan Zhang,Gildardo Aquino-Perez,Charles W. Whitfield,Susanta K. Behura,Stewart H. Berlocher,Walter S. Sheppard,Deborah R. Smith,Andrew V. Suarez,Neil D. Tsutsui,Xuehong Wei,David A. Wheeler,Paul Havlak,Bingshan Li,Yue Liu,Angela Jovilet,Sandra L. Lee,Lynne V. Nazareth,Ling Ling Pu,Rachel Thorn,Viktor Stolc,Thomas C. Newman,Manoj P. Samanta,Waraporn Tongprasit,Charles Claudianos,Charles Claudianos,May R. Berenbaum,Sunita Biswas,Sunita Biswas,Dirk C. de Graaf,René Feyereisen,Reed M. Johnson,John G. Oakeshott,Hilary Ranson,Mary A. Schuler,Donna M. Muzny,Joseph Chacko,Clay Davis,Huyen Dinh,Rachel Gill,Judith Hernandez,Sandra Hines,Jennifer Hume,La Ronda Jackson,Christie Kovar,Lora Lewis,George Miner,Margaret Morgan,Ngoc Nguyen,Geoffrey Okwuonu,Heidi Paul,Jireh Santibanez,Glenford Savery,Amanda F. Svatek,Donna Villasana,Rita A. Wright +228 more
TL;DR: The genome sequence of the honeybee Apis mellifera is reported, suggesting a novel African origin for the species A. melliferA and insights into whether Africanized bees spread throughout the New World via hybridization or displacement.
Journal ArticleDOI
Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization
Nicholas H. Putnam,Mansi Srivastava,Uffe Hellsten,Bill Dirks,Jarrod Chapman,Asaf Salamov,Astrid Terry,Harris Shapiro,Erika Lindquist,Vladimir V. Kapitonov,Jerzy Jurka,Grigory Genikhovich,Igor V. Grigoriev,Susan Lucas,Robert Steele,John R. Finnerty,Ulrich Technau,Mark Q. Martindale,Daniel S. Rokhsar,Daniel S. Rokhsar +19 more
TL;DR: A comparative analysis of the draft genome of an emerging cnidarian model, the starlet sea anemone Nematostella vectensis, suggests that gene “inventions” along the lineage leading to animals were likely already well integrated with preexisting eukaryotic genes in the eumetazoan progenitor.
Journal ArticleDOI
Hedgehog: functions and mechanisms
Markku Varjosalo,Jussi Taipale +1 more
TL;DR: This review focuses broadly on the current understanding of Hh signaling, from mechanisms of action to cellular and developmental functions, and the role of HH in the pathogenesis of human disease and the possibilities for therapeutic intervention.
Journal ArticleDOI
Signaling cross-talk between TGF-beta/BMP and other pathways.
Xing Guo,Xiao-Fan Wang +1 more
TL;DR: The different modes of cross-talk between TGF-β/BMP and the signaling pathways of Mitogen-activated protein kinase, phosphatidylinositol-3 kinase/Akt, Wnt, Hedgehog, Notch, and the interleukin/interferon-gamma/tumor necrosis factor-alpha cytokines are reviewed, with an emphasis on the underlying molecular mechanisms.
References
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Eric S. Lander,Lauren Linton,Bruce W. Birren,Chad Nusbaum,Michael C. Zody,Jennifer Baldwin,Keri Devon,Ken Dewar,Michael Doyle,William Fitzhugh,Roel Funke,Diane Gage,Katrina Harris,Andrew Heaford,John Howland,Lisa Kann,Jessica A. Lehoczky,Rosie Levine,Paul A. McEwan,Kevin McKernan,James Meldrim,Jill P. Mesirov,Cher Miranda,William Morris,Jerome Naylor,Christina Raymond,Mark Rosetti,Ralph Santos,Andrew Sheridan,Carrie Sougnez,Nicole Stange-Thomann,Nikola Stojanovic,Aravind Subramanian,Dudley Wyman,Jane Rogers,John Sulston,R Ainscough,Stephan Beck,David Bentley,John Burton,C M Clee,Nigel P. Carter,Alan Coulson,Rebecca Deadman,Panos Deloukas,Andrew Dunham,Ian Dunham,Richard Durbin,Lisa French,Darren Grafham,Simon G. Gregory,Tim Hubbard,Sean Humphray,Adrienne Hunt,Matthew Jones,Christine Lloyd,Amanda McMurray,Lucy Matthews,Simon Mercer,Sarah Milne,James C. Mullikin,Andrew J. Mungall,Robert W. Plumb,Mark T. Ross,Ratna Shownkeen,Sarah Sims,Robert H. Waterston,Richard K. Wilson,LaDeana W. Hillier,John Douglas Mcpherson,Marco A. Marra,Elaine R. Mardis,Lucinda Fulton,Asif T. Chinwalla,Kymberlie H. Pepin,Warren Gish,Stephanie L. Chissoe,Michael C. Wendl,Kim D. Delehaunty,Tracie L. Miner,Andrew Delehaunty,Jason B. Kramer,Lisa Cook,Robert S. Fulton,Douglas L. Johnson,Patrick Minx,Sandra W. Clifton,Trevor Hawkins,Elbert Branscomb,Paul Predki,Paul G. Richardson,Sarah Wenning,Tom Slezak,Norman A. Doggett,Jan Fang Cheng,Anne S. Olsen,Susan Lucas,Christopher J. Elkin,Edward Uberbacher,Marvin Frazier,Richard A. Gibbs,Donna M. Muzny,Steven E. Scherer,John Bouck,Erica Sodergren,Kim C. Worley,Catherine M. Rives,James H. Gorrell,Michael L. Metzker,Susan L. Naylor,Raju Kucherlapati,David L. Nelson,George M. Weinstock,Yoshiyuki Sakaki,Asao Fujiyama,Masahira Hattori,Tetsushi Yada,Atsushi Toyoda,Takehiko Itoh,Chiharu Kawagoe,Hidemi Watanabe,Yasushi Totoki,Todd D. Taylor,Jean Weissenbach,Roland Heilig,William Saurin,François Artiguenave,Philippe Brottier,Thomas Brüls,Eric Pelletier,Catherine Robert,Patrick Wincker,André Rosenthal,Matthias Platzer,Gerald Nyakatura,Stefan Taudien,Andreas Rump,Douglas R. Smith,Lynn Doucette-Stamm,Marc Rubenfield,Keith Weinstock,Mei Lee Hong,Joann Dubois,Huanming Yang,Jun Yu,Jian Wang,Guyang Huang,Jun Gu,Leroy Hood,Lee Rowen,Anup Madan,Shizen Qin,Ronald W. Davis,Nancy A. Federspiel,A. Pia Abola,Michael Proctor,Bruce A. Roe,Feng Chen,Huaqin Pan,Juliane Ramser,Hans Lehrach,Richard Reinhardt,W. Richard McCombie,Melissa De La Bastide,Neilay Dedhia,H. Blöcker,K. Hornischer,Gabriele Nordsiek,Richa Agarwala,L. Aravind,Jeffrey A. Bailey,Alex Bateman,Serafim Batzoglou,Ewan Birney,Peer Bork,Daniel G. Brown,Christopher B. Burge,Lorenzo Cerutti,Hsiu Chuan Chen,Deanna M. Church,Michele Clamp,Richard R. Copley,Tobias Doerks,Sean R. Eddy,Evan E. Eichler,Terrence S. Furey,James E. Galagan,James G. R. Gilbert,Cyrus L. Harmon,Yoshihide Hayashizaki,David Haussler,Henning Hermjakob,Karsten Hokamp,Wonhee Jang,L. Steven Johnson,Thomas A. Jones,Simon Kasif,Arek Kaspryzk,Scot Kennedy,W. James Kent,Paul Kitts,Eugene V. Koonin,Ian F Korf,David Kulp,Doron Lancet,Todd M. Lowe,Aoife McLysaght,Tarjei S. Mikkelsen,John V. Moran,Nicola Mulder,Victor J. Pollara,Chris P. Ponting,Greg Schuler,Jörg Schultz,Guy Slater,Arian F.A. Smit,Elia Stupka,Joseph Szustakowki,Danielle Thierry-Mieg,Jean Thierry-Mieg,Lukas Wagner,John W. Wallis,Raymond Wheeler,Alan Williams,Yuri I. Wolf,Kenneth H. Wolfe,Shiaw Pyng Yang,Ru Fang Yeh,Francis S. Collins,Mark S. Guyer,Jane Peterson,Adam Felsenfeld,Kris A. Wetterstrand,Richard M. Myers,Jeremy Schmutz,Mark Dickson,Jane Grimwood,David R. Cox,Maynard V. Olson,Rajinder Kaul,Christopher K. Raymond,Nobuyoshi Shimizu,Kazuhiko Kawasaki,Shinsei Minoshima,Glen A. Evans,Maria Athanasiou,Roger A. Schultz,Aristides Patrinos,Michael J. Morgan +248 more
TL;DR: The results of an international collaboration to produce and make freely available a draft sequence of the human genome are reported and an initial analysis is presented, describing some of the insights that can be gleaned from the sequence.
Journal ArticleDOI
The sequence of the human genome.
J. Craig Venter,Mark Raymond Adams,Eugene W. Myers,Peter W. Li,Richard J. Mural,Granger G. Sutton,Hamilton O. Smith,Mark Yandell,Cheryl A. Evans,Robert A. Holt,Jeannine D. Gocayne,Peter Amanatides,Richard M. Ballew,Daniel H. Huson,Jennifer R. Wortman,Qing Zhang,Chinnappa D. Kodira,Xiangqun H. Zheng,Lin Chen,Marian P. Skupski,Gangadharan Subramanian,Paul Thomas,Jinghui Zhang,George L. Gabor Miklos,Catherine R. Nelson,Samuel Broder,Andrew G. Clark,J. H. Nadeau,Victor A. McKusick,Norton D. Zinder,Arnold J. Levine,Richard J. Roberts,M. I. Simon,Carolyn W. Slayman,Michael W. Hunkapiller,Randall Bolanos,Arthur L. Delcher,Ian M. Dew,Daniel Fasulo,Michael Flanigan,Liliana Florea,Aaron L. Halpern,Sridhar Hannenhalli,Saul A. Kravitz,Samuel Levy,Clark M. Mobarry,Knut Reinert,Karin A. Remington,Jane Abu-Threideh,Ellen M. Beasley,Kendra Biddick,Vivien Bonazzi,Rhonda Brandon,Michele Cargill,Ishwar Chandramouliswaran,Rosane Charlab,Kabir Chaturvedi,Zuoming Deng,Valentina Di Francesco,Patrick Dunn,Karen Eilbeck,Carlos Evangelista,Andrei Gabrielian,Weiniu Gan,Wangmao Ge,Fangcheng Gong,Zhiping Gu,Ping Guan,Thomas J. Heiman,Maureen E. Higgins,Rui-Ru Ji,Zhaoxi Ke,Karen A. Ketchum,Zhongwu Lai,Yiding Lei,Zhenya Li,Jiayin Li,Yong Liang,Xiaoying Lin,Fu Lu,Gennady V. Merkulov,Natalia Milshina,Helen M. Moore,Ashwinikumar K Naik,Vaibhav A. Narayan,Beena Neelam,Deborah Nusskern,Douglas B. Rusch,Steven L. Salzberg,Wei Shao,Bixiong Chris Shue,Jingtao Sun,Zhen Yuan Wang,Aihui Wang,Xin Wang,Jian Wang,Ming-Hui Wei,Ron Wides,Chunlin Xiao,Chunhua Yan,Alison Yao,Jane Ye,Ming Zhan,Weiqing Zhang,Hongyu Zhang,Qi Zhao,Liansheng Zheng,Fei Zhong,Wenyan Zhong,Shiaoping C. Zhu,Shaying Zhao,Dennis A. Gilbert,Suzanna Baumhueter,Gene Spier,Christine Carter,Anibal Cravchik,Trevor Woodage,Feroze Ali,Huijin An,Aderonke Awe,Danita Baldwin,Holly Baden,Mary Barnstead,Ian Barrow,Karen Beeson,Dana A. Busam,Amy Carver,Ming Lai Cheng,Liz Curry,Steve Danaher,Lionel Davenport,Raymond Desilets,Susanne Dietz,Kristina Dodson,Lisa Doup,Steven Ferriera,Neha Garg,Andres Gluecksmann,Brit J. Hart,Jason Haynes,Charles Haynes,Cheryl Heiner,Suzanne Hladun,Damon Hostin,Jarrett Houck,Timothy Howland,Chinyere Ibegwam,Jeffery Johnson,Francis Kalush,Lesley Kline,Shashi Koduru,Amy Love,Felecia Mann,David May,Steven McCawley,Tina C. McIntosh,Ivy McMullen,Mee Moy,Linda Moy,Brian Murphy,Keith Nelson,Cynthia Pfannkoch,Eric Pratts,Vinita Puri,Hina Qureshi,Matthew Reardon,Robert Rodriguez,Yu-Hui Rogers,Deanna Romblad,Bob Ruhfel,Richard T. Scott,Cynthia Sitter,Michelle Smallwood,Erin Stewart,Renee Strong,Ellen Suh,Reginald Thomas,Ni Ni Tint,Sukyee Tse,Claire Vech,Gary Wang,Jeremy Wetter,Sherita Williams,Monica Williams,Sandra Windsor,Emily Winn-Deen,Keriellen Wolfe,Jayshree Zaveri,Karena Zaveri,Josep F. Abril,Roderic Guigó,Michael J. Campbell,Kimmen Sjölander,Brian Karlak,Anish Kejariwal,Huaiyu Mi,Betty Lazareva,Thomas Hatton,Apurva Narechania,Karen Diemer,Anushya Muruganujan,Nan Guo,Shinji Sato,Vineet Bafna,Sorin Istrail,Ross Lippert,Russell Schwartz,Brian P. Walenz,Shibu Yooseph,David Allen,Anand Basu,James Baxendale,Louis Blick,Marcelo Caminha,John Carnes-Stine,Parris Caulk,Yen-Hui Chiang,My Coyne,Carl Dahlke,Anne Deslattes Mays,Maria Dombroski,Michael Donnelly,Dale Ely,Shiva Esparham,Carl Fosler,Harold Gire,Stephen Glanowski,Kenneth Glasser,Anna Glodek,Mark Gorokhov,Ken Graham,Barry Gropman,Michael Harris,Jeremy Heil,Scott Henderson,Jeffrey Hoover,Donald Jennings,Catherine Jordan,James Jordan,John Kasha,Leonid Kagan,Cheryl L. Kraft,Alexander Levitsky,Mark Lewis,Xiangjun Liu,John Lopez,Daniel Ma,William H. Majoros,Joe McDaniel,Sean C. Murphy,Matthew Newman,Trung Hieu Nguyen,Ngoc Nguyen,Marc Nodell,Sue Pan,Jim Peck,Marshall Peterson,William Rowe,Robert Sanders,John Scott,Michael Simpson,Thomas J. Smith,Arlan Sprague,Timothy B. Stockwell,Russell Turner,Eli Venter,Mei Wang,Meiyuan Wen,David Wu,Mitchell Wu,Ashley Xia,Ali Zandieh,Xiaohong Zhu +272 more
TL;DR: Comparative genomic analysis indicates vertebrate expansions of genes associated with neuronal function, with tissue-specific developmental regulation, and with the hemostasis and immune systems are indicated.
Journal ArticleDOI
Sequence the Human Genome
TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
Journal ArticleDOI
Genome sequence of the human malaria parasite Plasmodium falciparum
Malcolm J. Gardner,Neil Hall,Eula Fung,Owen White,Matthew Berriman,Richard W. Hyman,Jane M. Carlton,Arnab Pain,Karen E. Nelson,Sharen Bowman,Ian T. Paulsen,Keith D. James,Jonathan A. Eisen,Kim Rutherford,Steven L. Salzberg,Alister Craig,Sue Kyes,Man Suen Chan,Vishvanath Nene,Shamira J. Shallom,Bernard B. Suh,Jeremy Peterson,Samuel V. Angiuoli,Mihaela Pertea,Jonathan E. Allen,Jeremy D. Selengut,Daniel H. Haft,Michael W. Mather,Akhil B. Vaidya,David M. A. Martin,Alan H. Fairlamb,Martin Fraunholz,David S. Roos,Stuart A. Ralph,Geoffrey I. McFadden,Leda M. Cummings,G. Mani Subramanian,Christopher J. Mungall,J. Craig Venter,Daniel J. Carucci,Stephen L. Hoffman,Chris I. Newbold,Ronald W. Davis,Claire M. Fraser,Bart Barrell +44 more
TL;DR: The genome sequence of P. falciparum clone 3D7 is reported, which is the most (A + T)-rich genome sequenced to date and is being exploited in the search for new drugs and vaccines to fight malaria.
Journal ArticleDOI
The evolutionary fate and consequences of duplicate genes
Michael Lynch,John S. Conery +1 more
TL;DR: Although duplicate genes may only rarely evolve new functions, the stochastic silencing of such genes may play a significant role in the passive origin of new species.
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