E
Eric Kim
Researcher at University of California, Los Angeles
Publications - 35
Citations - 1667
Eric Kim is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Computer science & Object (computer science). The author has an hindex of 15, co-authored 33 publications receiving 1277 citations. Previous affiliations of Eric Kim include University of California, Berkeley.
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Journal ArticleDOI
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Georg Ehret,Georg Ehret,Teresa Ferreira,Daniel I. Chasman,Anne U. Jackson,Ellen M. Schmidt,Toby Johnson,Toby Johnson,Gudmar Thorleifsson,Jian'an Luan,Louise A. Donnelly,Stavroula Kanoni,Ann-Kristin Petersen,Vasyl Pihur,Rona J. Strawbridge,Dmitry Shungin,Dmitry Shungin,Maria Hughes,Osorio Meirelles,Marika Kaakinen,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Kati Kristiansson,Kati Kristiansson,Sonia Shah,Marcus E. Kleber,Xiuqing Guo,Leo-Pekka Lyytikäinen,Cristiano Fava,Cristiano Fava,Niclas Eriksson,Ilja M. Nolte,Patrik K. E. Magnusson,Elias Salfati,Loukianos S. Rallidis,Elizabeth Theusch,Andrew J. Smith,Lasse Folkersen,Kate Witkowska,Tune H. Pers,Roby Joehanes,Stuart K. Kim,Lazaros Lataniotis,Rick Jansen,Andrew D. Johnson,Helen R. Warren,Young Jin Kim,Wei Zhao,Ying Wu,Bamidele O. Tayo,Murielle Bochud,Devin Absher,Linda S. Adair,Najaf Amin,Dan E. Arking,Tomas Axelsson,Damiano Baldassarre,Beverley Balkau,Stefania Bandinelli,Michael R. Barnes,Inês Barroso,Inês Barroso,Stephen Bevan,Joshua C. Bis,Gyda Bjornsdottir,Michael Boehnke,Eric Boerwinkle,Lori L. Bonnycastle,Dorret I. Boomsma,Stefan R. Bornstein,Morris Brown,Michel Burnier,Claudia P. Cabrera,John C. Chambers,John C. Chambers,John C. Chambers,I. Shou Chang,Ching-Yu Cheng,Ching-Yu Cheng,Peter S. Chines,Ren-Hua Chung,Francis S. Collins,John M. C. Connell,Angela Döring,Jean Dallongeville,John Danesh,John Danesh,Ulf de Faire,Graciela E. Delgado,Anna F. Dominiczak,Alex S. F. Doney,Fotios Drenos,Fotios Drenos,Sarah Edkins,John D. Eicher,Roberto Elosua,Stefan Enroth,Jeanette Erdmann,Per Eriksson,Tõnu Esko,Tõnu Esko,Tõnu Esko,Evangelos Evangelou,Evangelos Evangelou,Alun Evans,Tove Fall,Martin Farrall,Janine F. Felix,Jean Ferrières,Luigi Ferrucci,Myriam Fornage,Terrence Forrester,Nora Franceschini,Oscar H. Franco,Anders Franco-Cereceda,Ross M. Fraser,Santhi K. Ganesh,He Gao,Karl Gertow,Francesco Gianfagna,Bruna Gigante,Franco Giulianini,Anuj Goel,Alison H. Goodall,Alison H. Goodall,Mark O. Goodarzi,Mathias Gorski,Jürgen Gräßler,Christopher J. Groves,Vilmundur Gudnason,Ulf Gyllensten,Göran Hallmans,Anna-Liisa Hartikainen,Maija Hassinen,Aki S. Havulinna,Caroline Hayward,Serge Hercberg,Karl-Heinz Herzig,Andrew A. Hicks,Aroon D. Hingorani,Joel N. Hirschhorn,Joel N. Hirschhorn,Albert Hofman,Albert Hofman,Jostein Holmen,Oddgeir L. Holmen,Jouke-Jan Hottenga,Phil Howard,Chao A. Hsiung,Steven C. Hunt,Steven C. Hunt,M. Arfan Ikram,Thomas Illig,Carlos Iribarren,Richard A. Jensen,Mika Kähönen,Hyun Min Kang,Sekar Kathiresan,Sekar Kathiresan,Brendan J. Keating,Kay-Tee Khaw,Yun Kyoung Kim,Eric Kim,Mika Kivimäki,Norman Klopp,Genovefa Kolovou,Pirjo Komulainen,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Gulum Kosova,Gulum Kosova,Ronald M. Krauss,Diana Kuh,Zoltán Kutalik,Zoltán Kutalik,Johanna Kuusisto,Kirsti Kvaløy,Timo A. Lakka,Nanette R. Lee,I. Te Lee,Wen Jane Lee,Daniel Levy,Xiaohui Li,Kae Woei Liang,Honghuang Lin,Honghuang Lin,Li Lin,Jaana Lindström,Stéphane Lobbens,Stéphane Lobbens,Satu Männistö,Gabriele Müller,Martina Müller-Nurasyid,François Mach,Hugh S. Markus,Eirini Marouli,Eirini Marouli,Mark I. McCarthy,Colin A. McKenzie,Pierre Meneton,Cristina Menni,Andres Metspalu,Vladan Mijatovic,Leena Moilanen,Leena Moilanen,May E. Montasser,Andrew D. Morris,Alanna C. Morrison,Antonella Mulas,Ramaiah Nagaraja,Narisu Narisu,Kjell Nikus,Christopher J. O'Donnell,Christopher J. O'Donnell,Paul F. O'Reilly,Ken K. Ong,Fred Paccaud,Cameron D. Palmer,Cameron D. Palmer,Afshin Parsa,Nancy L. Pedersen,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Markus Perola,Markus Perola,Markus Perola,Annette Peters,Neil Poulter,Peter P. Pramstaller,Bruce M. Psaty,Bruce M. Psaty,Bruce M. Psaty,Thomas Quertermous,Dabeeru C. Rao,Asif Rasheed,N. William Rayner,N. William Rayner,Frida Renström,Frida Renström,Rainer Rettig,Kenneth Rice,Robert Roberts,Lynda M. Rose,Jacques E. Rossouw,Nilesh J. Samani,Nilesh J. Samani,Serena Sanna,Jouko Saramies,Heribert Schunkert,Sylvain Sebert,Sylvain Sebert,Wayne Huey-Herng Sheu,Wayne Huey-Herng Sheu,Young Ah Shin,Xueling Sim,Xueling Sim,Johannes H. Smit,Albert V. Smith,Maria X. Sosa,Tim D. Spector,Alena Stančáková,Alice Stanton,Kathleen Stirrups,Kathleen Stirrups,Heather M. Stringham,Johan Sundström,Amy J. Swift,Ann-Christine Syvänen,E. Shyong Tai,Toshiko Tanaka,Kirill V. Tarasov,Alexander Teumer,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Martin D. Tobin,Elena Tremoli,André G. Uitterlinden,Matti Uusitupa,Ahmad Vaez,Ahmad Vaez,Dhananjay Vaidya,Cornelia M. van Duijn,Erik P A Van Iperen,Ramachandran S. Vasan,Ramachandran S. Vasan,Germaine C. Verwoert,Jarmo Virtamo,Veronique Vitart,Benjamin F. Voight,Peter Vollenweider,Aline Wagner,Louise V. Wain,Nicholas J. Wareham,Hugh Watkins,Alan B. Weder,Harm-Jan Westra,Rainford J. Wilks,Tom Wilsgaard,James F. Wilson,Tien Yin Wong,Tien Yin Wong,Tsun-Po Yang,Tsun-Po Yang,Jie Yao,Loic Yengo,Loic Yengo,Weihua Zhang,Weihua Zhang,Jing Hua Zhao,Xiaofeng Zhu,Pascal Bovet,Richard S. Cooper,Karen L. Mohlke,Danish Saleheen,Jong-Young Lee,Paul Elliott,Hinco J. Gierman,Hinco J. Gierman,Cristen J. Willer,Lude Franke,G. Kees Hovingh,Kent D. Taylor,George Dedoussis,Peter S. Sever,Andrew Wong,Lars Lind,Themistocles L. Assimes,Inger Njølstad,Peter Schwarz,Claudia Langenberg,Harold Snieder,Mark J. Caulfield,Olle Melander,Markku Laakso,Juha Saltevo,Rainer Rauramaa,Jaakko Tuomilehto,Erik Ingelsson,Erik Ingelsson,Terho Lehtimäki,Kristian Hveem,Walter Palmas,Winfried März,Winfried März,Meena Kumari,Veikko Salomaa,Yii-Der Ida Chen,Jerome I. Rotter,Philippe Froguel,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Edward G. Lakatta,Kari Kuulasmaa,Paul W. Franks,Paul W. Franks,Paul W. Franks,Anders Hamsten,H.-Erich Wichmann,H.-Erich Wichmann,Colin N. A. Palmer,Kari Stefansson,Kari Stefansson,Paul M. Ridker,Ruth J. F. Loos,Ruth J. F. Loos,Aravinda Chakravarti,Panos Deloukas,Panos Deloukas,Andrew P. Morris,Andrew P. Morris,Christopher Newton-Cheh,Christopher Newton-Cheh,Christopher Newton-Cheh,Patricia B. Munroe +375 more
TL;DR: In this article, the authors identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals, and 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues.
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Georg Ehret,Teresa Ferreira,Daniel I. Chasman,Anne U. Jackson,Ellen M. Schmidt,Toby Johnson,Gudmar Thorleifsson,Jian'an Luan,Louise A. Donnelly,Stavroula Kanoni,Ann-Kristin Petersen,Vasyl Pihurl,Rona J. Strawbridge,Dmitry Shungin,Maria Hughes,Osorio Meirelles,Marika Kaakinen,Nabila Bouatia-Naji,Kati Kristiansson,Sonia Shah,Marcus E. Kleber,Xiuqing Guo,Leo-Pekka Lyytikäinen,Cristiano Fava,Nidas Eriksson,Ilja M. Nolte,Patrik K. E. Magnusson,Elias Salfati,Loukianos S. Rallidis,Elizabeth Theusch,Andrew J. Smith,Lasse Folkersen,Kate Witkowska,Tune H. Pers,Roby Joehanes,Stuart K. Kim,Lazaros Lataniotis,Rick Jansen,Andrew D. Johnson,Helen R. Warren,Young Jin Kim,Wei Zhao,Ying Wu,Bamidele O. Tayo,Murielle Bochud,Devin Absher,Linda S. Adair,Najaf Amin,Dan E. Arkingl,Tomas Axelsson,Damian Baldassarre,Beverley Balkau,Stefania Bandinelli,Michael R. Barnes,Inês Barroso,Stephen Bevan,Joshua C. Bis,Gyda Bjornsdottir,Michael Boehnke,Eric Boerwinkle,Lori L. Bonnycastle,Dorret I. Boomsma,Stefan R. Bornstein,Morris Brown,Michel Burnier,Claudia P. Cabrera,John C. Chambers,I-Shou Chang,Ching-Yu Cheng,Peter S. Chines,Ren-Hua Chung,Francis S. Collins,John M. C. Connell,Angela Döring,Jean Dallongeville,John Danesh,Ulf de Faire,Graciela E. Delgado,Anna F. Dominiczak,Alex S. F. Doney,Fotios Drenos,Sarah Edkins,John D. Eicher,Roberto Elosua,Stefan Enroth,Jeanette Erdmann,Per Eriksson,Tõnu Esko,Evangelos Evangelou,Alun Evans,Tove Fai,Martin Farra,Janine F. Felixl,Jean Ferrières,Luigi Ferrucci,Myriam Fornage,Terrence Forrester,Nora Franceschinil,Oscar H. Franco,Anders Franco-Cereceda,Ross M. Fraser,Santhi K. Ganesh,He Gao,Karl Gertow,Francesco Gianfagna,Bruna Gigante,Franco Giulianini,Anuj Goe,Alison H. Goodall,Mark O. Goodarzi,Mathias Gorski,Jürgen Grässler,Christopher J. Groves,Vilmundur Gudnason,Ulf Gyllensten,Göran Hallmans,Anna-Liisa Hartikainen,Maija Hassinen,Aki S. Havulinna,Caroline Hayward,Serge Hercberg,Karl-Heinz Herzig,Andrew A. Hicks,Aroon D. Hingorani,Joel N. Hirschhorn,Albert Hofmanl,Jostein Holmen,Oddgeir L. Holmen,Jouke-Jan Hottenga,Phil Howard,Chao A. Hsiung,Steven C. Hunt,M. Arfan Ikram,Thomas Illig,Carlos Iribarren,Richard A. Jensen,Mika Kähönen,Hyun Min Kang,Sekar Kathiresan,Brendan J. Keating,Kay-Tee Khaw,Yun Kyoung Kim,Eric Kim,Mika Kivimäki,Norman Klopp,Genovefa Kolovou,Pirjo Komulainen,Jaspal S. Kooner,Gulum Kosova,Ronald M. Krauss,Diana Kuh,Zoltán Kutalik,Johanna Kuusisto,Kirsti Kvaløy,Timo A. Lakka,Nanette R. Lee,I-Te Lee,Wen-Jane Lee,Daniel Levy,Xiaohui Li,Kae-Woei Liang,Honghuang Lin,Li Lin,Jaana Lindström,Stéphane Lobbens,Satu Männistö,Gabriele Müller,Martina Müller-Nurasyid,François Mach,Hugh S. Markus,Eirini Marouli,Mark I. McCarthy,Colin A. McKenzie,Pierre Meneton,Cristina Menni,Andres Metspalu,Vladan Mijatovic,Leena Moilanen,May E. Montasser,Andrew D. Morris,Alanna C. Morrison,Antonella Mulas,Ramaiah Nagaraja,Narisu Narisu,Kjell Nikus,Christopher J. O'Donnell,Paul F. O'Reilly,Ken K. Ong,Fred Paccaud,Cameron D. Palmer,Afshin Parsa,Nancy L. Pedersen,Brenda W.J.H. Penninx,Markus Perola,Annette Peters,Neil Poulter,Peter P. Pramstaller,Bruce M. Psaty,Thomas Quertermous,Dabeeru C. Rao,Asif Rasheed,N. William Rayner,Frida Renström,Rainer Rettig,Kenneth Rice,Robert Roberts,Lynda M. Rose,Jacques E. Rossouw,Nilesh J. Samani,Serena Sanna,Jouko Saramies,Heribert Schunkert,Sylvain Sebert,Wayne H-H Sheu,Young-Ah Shin,Xueling Sim,Johannes H. Smit,Albert V. Smith,Maria X. Sosa,Tim D. Spector,Alena Stančáková,Alice Stanton,Kathleen Stirrups,Heather M. Stringham,Johan Sundström,Amy J. Swift,Ann-Christine Syvänen,E-Shyong Tai,Toshiko Tanaka,Kirill Tarasov,Alexander Teumer,Unnur Thorsteinsdottir,Martin D. Tobin,Elena Tremoli,André G. Uitterlinden,Matti Uusitupa,Ahmad Vaez,Dhananjay Vaidya,Cornelia M. van Duijn,Erik P A Van Iperen,Ramachandran S. Vasan,Germaine C. Verwoert,Jarmo Virtamo,Veronique Vitart,Benjamin F. Voight,Peter Vollenweider,Aline Wagner,Louise V. Wain,Nicholas J. Wareham,Hugh Watldns,Alan B. Weder,Harm-Jan Westra,Rainford J. Wilks,Tom Wilsgaard,James F. Wilson,Tien Yin Wong,Tsun-Po Yang,Jie Yao,Loic Yengo,Weihua Zhang,Jing Hua Zhao,Xiaofeng Zhu,Pascal Bovet,Richard S. Cooper,Karen L. Mohlke,Danish Saleheen,Jong-Young Lee,Paul Elliott,Hinco J. Gierman,Cristen J. Willer,Lude Franke,G. Kees Hovingh,Kent D. Taylor,George Dedoussis,Peter S. Sever,Andrew Wong,Lars Lind,Themistocles L. Assimes,Inger Njølstad,Peter Schwarz,Claudia Langenberg,Harold Snieder,Mark J. Caulfield,E. Melander,Markku Laakso,Juha Saltevo,Rainer Rauramaa,Jaakko Tuomilehto,Erik Ingelsson,Terho Lehtimäki,Kristian Hveem,Walter Palmas,Winfried März,Meena Kumar,Veikko Salomaa,Yii-Der Ida Chen,Jerome I. Rotter,Philippe Froguel,Marjo-Riitta Järvelin,Edward G. Lakatta,Kari Kuulasmaa,Paul W. Franks,Anders Hamsten,H-Erich Wichmann,Colin N. A. Palmer,Kari Stefansson,Paul M. Ridker,Ruth J. F. Loos,Aravinda Chalcravarti,Panos Deloukas,Andrew P. Morris,Christopher Newton-Cheh,Patricia B. Munroe +312 more
TL;DR: The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney, expanding current knowledge of blood pressure–related pathways and highlighting tissues beyond the classical renal system in blood pressure regulation.
Journal ArticleDOI
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Valérie Turcot,Yingchang Lu,Yingchang Lu,Heather M. Highland,Heather M. Highland,Claudia Schurmann,Anne E. Justice,Rebecca S. Fine,Rebecca S. Fine,Jonathan P. Bradfield,Tõnu Esko,Tõnu Esko,Tõnu Esko,Ayush Giri,Mariaelisa Graff,Xiuqing Guo,Audrey E. Hendricks,Audrey E. Hendricks,Tugce Karaderi,Tugce Karaderi,Adelheid Lempradl,Adam E. Locke,Adam E. Locke,Anubha Mahajan,Eirini Marouli,Suthesh Sivapalaratnam,Suthesh Sivapalaratnam,Suthesh Sivapalaratnam,Kristin L. Young,Tamuno Alfred,Mary F. Feitosa,Nicholas G. D. Masca,Nicholas G. D. Masca,Alisa K. Manning,Alisa K. Manning,Carolina Medina-Gomez,Poorva Mudgal,Maggie C.Y. Ng,Alexander P. Reiner,Alexander P. Reiner,Sailaja Vedantam,Sailaja Vedantam,Sara M. Willems,Thomas W. Winkler,Gonçalo R. Abecasis,Katja K.H. Aben,Dewan S. Alam,Sameer E. Al-Harthi,Sameer E. Al-Harthi,Matthew A. Allison,Philippe Amouyel,Philippe Amouyel,Philippe Amouyel,Folkert W. Asselbergs,Folkert W. Asselbergs,Paul L. Auer,Beverley Balkau,Lia E. Bang,Inês Barroso,Inês Barroso,Lisa Bastarache,Marianne Benn,Sven Bergmann,Sven Bergmann,Lawrence F. Bielak,Matthias Blüher,Michael Boehnke,Heiner Boeing,Eric Boerwinkle,Eric Boerwinkle,Carsten A. Böger,Jette Bork-Jensen,Michiel L. Bots,Erwin P. Bottinger,Donald W. Bowden,Ivan Brandslund,Gerome Breen,Gerome Breen,Murray H. Brilliant,Linda Broer,Marco Brumat,Amber A. Burt,Adam S. Butterworth,Peter T. Campbell,Stefania Cappellani,David J. Carey,Eulalia Catamo,Mark J. Caulfield,John C. Chambers,John C. Chambers,Daniel I. Chasman,Daniel I. Chasman,Yii-Der Ida Chen,Rajiv Chowdhury,Cramer Christensen,Audrey Y. Chu,Audrey Y. Chu,Massimiliano Cocca,Francis S. Collins,James P. Cook,Janie Corley,Jordi Corominas Galbany,Amanda J. Cox,Amanda J. Cox,David S. Crosslin,Gabriel Cuellar-Partida,Gabriel Cuellar-Partida,Angela D'Eustacchio,John Danesh,John Danesh,Gail Davies,Gail Davies,Paul I.W. de Bakker,Mark C.H. De Groot,Renée de Mutsert,Ian J. Deary,Ian J. Deary,George Dedoussis,Ellen W. Demerath,Martin den Heijer,Anneke I. den Hollander,Hester M. den Ruijter,Joe Dennis,Josh C. Denny,Emanuele Di Angelantonio,Fotios Drenos,Fotios Drenos,Mengmeng Du,Mengmeng Du,Marie-Pierre Dubé,Alison M. Dunning,Douglas F. Easton,Todd L. Edwards,David Ellinghaus,Patrick T. Ellinor,Patrick T. Ellinor,Paul Elliott,Evangelos Evangelou,Evangelos Evangelou,Aliki-Eleni Farmaki,Aliki-Eleni Farmaki,I. Sadaf Farooqi,Jessica D. Faul,Sascha Fauser,Shuang Feng,Ele Ferrannini,Jean Ferrières,Jose C. Florez,Jose C. Florez,Ian Ford,Myriam Fornage,Oscar H. Franco,Andre Franke,Paul W. Franks,Paul W. Franks,Paul W. Franks,Nele Friedrich,Ruth Frikke-Schmidt,Tessel E. Galesloot,Wei Gan,Ilaria Gandin,Paolo Gasparini,Jane Gibson,Vilmantas Giedraitis,Anette P. Gjesing,Penny Gordon-Larsen,Mathias Gorski,Hans-Jörgen Grabe,Hans-Jörgen Grabe,Struan F.A. Grant,Niels Grarup,Helen Griffiths,Megan L. Grove,Vilmundur Gudnason,Stefan Gustafsson,Jeffrey Haessler,Hakon Hakonarson,Anke R. Hammerschlag,Torben Hansen,Kathleen Mullan Harris,Tamara B. Harris,Andrew T. Hattersley,Christian Theil Have,Caroline Hayward,Liang He,Liang He,Nancy L. Heard-Costa,Nancy L. Heard-Costa,Andrew C. Heath,Iris M. Heid,Øyvind Helgeland,Jussi Hernesniemi,Alex W. Hewitt,Alex W. Hewitt,Alex W. Hewitt,Oddgeir L. Holmen,G. Kees Hovingh,Joanna M. M. Howson,Yao Hu,Paul L. Huang,Jennifer E. Huffman,M. Arfan Ikram,Erik Ingelsson,Erik Ingelsson,Anne U. Jackson,Jan-Håkan Jansson,Gail P. Jarvik,Gorm B. Jensen,Yucheng Jia,Stefan Johansson,Marit E. Jørgensen,Marit E. Jørgensen,Torben Jørgensen,Torben Jørgensen,J. Wouter Jukema,Bratati Kahali,Bratati Kahali,René S. Kahn,Mika Kähönen,Pia R. Kamstrup,Stavroula Kanoni,Jaakko Kaprio,Jaakko Kaprio,Maria Karaleftheri,Sharon L.R. Kardia,Fredrik Karpe,Sekar Kathiresan,Sekar Kathiresan,Frank Kee,Lambertus A. Kiemeney,Eric Kim,Hidetoshi Kitajima,Pirjo Komulainen,Jaspal S. Kooner,Jaspal S. Kooner,Charles Kooperberg,Tellervo Korhonen,Tellervo Korhonen,Tellervo Korhonen,Peter Kovacs,Helena Kuivaniemi,Helena Kuivaniemi,Zoltán Kutalik,Zoltán Kutalik,Kari Kuulasmaa,Johanna Kuusisto,Markku Laakso,Timo A. Lakka,David Lamparter,David Lamparter,Ethan M. Lange,Leslie A. Lange,Claudia Langenberg,Eric B. Larson,Eric B. Larson,Nanette R. Lee,Terho Lehtimäki,Cora E. Lewis,Huaixing Li,Jin Li,Ruifang Li-Gao,Honghuang Lin,Keng-Hung Lin,Li-An Lin,Xu Lin,Lars Lind,Jaana Lindström,Allan Linneberg,Ching-Ti Liu,Dajiang J. Liu,Yongmei Liu,Ken Sin Lo,Artitaya Lophatananon,Andrew J. Lotery,Anu Loukola,Jian'an Luan,Steven A. Lubitz,Steven A. Lubitz,Leo-Pekka Lyytikäinen,Satu Männistö,Gaëlle Marenne,Angela L. Mazul,Mark I. McCarthy,Roberta McKean-Cowdin,Sarah E. Medland,Karina Meidtner,Lili Milani,Vanisha Mistry,Paul Mitchell,Karen L. Mohlke,Leena Moilanen,Marie Moitry,Grant W. Montgomery,Grant W. Montgomery,Dennis O. Mook-Kanamori,Carmel Moore,Trevor A. Mori,Andrew D. Morris,Andrew P. Morris,Andrew P. Morris,Martina Müller-Nurasyid,Patricia B. Munroe,Mike A. Nalls,Narisu Narisu,Christopher P. Nelson,Christopher P. Nelson,Matt Neville,Sune F. Nielsen,Kjell Nikus,Pål R. Njølstad,Børge G. Nordestgaard,Dale R. Nyholt,Dale R. Nyholt,Jeffrey R. O'Connel,Michelle L. O'Donoghue,Loes M. Olde Loohuis,Roel A. Ophoff,Roel A. Ophoff,Katharine R. Owen,Chris J. Packard,Sandosh Padmanabhan,Colin N. A. Palmer,Nicholette D. Palmer,Gerard Pasterkamp,Aniruddh P. Patel,Aniruddh P. Patel,Alison Pattie,Oluf Pedersen,Peggy L. Peissig,Gina M. Peloso,Craig E. Pennell,Markus Perola,Markus Perola,Markus Perola,James A. Perry,John R. B. Perry,Tune H. Pers,Tune H. Pers,Thomas N. Person,Annette Peters,Eva Rb Petersen,Patricia A. Peyser,Ailith Pirie,Ozren Polasek,Ozren Polasek,Tinca J. C. Polderman,Hannu Puolijoki,Olli T. Raitakari,Asif Rasheed,Rainer Rauramaa,Dermot F. Reilly,Frida Renström,Frida Renström,Myriam Rheinberger,Paul M. Ridker,John D. Rioux,Manuel A. Rivas,Manuel A. Rivas,David J. Roberts,David J. Roberts,David J. Roberts,Neil R. Robertson,Antonietta Robino,Olov Rolandsson,Igor Rudan,Katherine S. Ruth,Danish Saleheen,Veikko Salomaa,Nilesh J. Samani,Nilesh J. Samani,Yadav Sapkota,Naveed Sattar,Robert E. Schoen,Pamela J. Schreiner,Matthias B. Schulze,Robert A. Scott,Marcelo P. Segura-Lepe,Svati H. Shah,Wayne H-H Sheu,Wayne H-H Sheu,Xueling Sim,Xueling Sim,Andrew J. Slater,Kerrin S. Small,Albert V. Smith,Lorraine Southam,Lorraine Southam,Tim D. Spector,Elizabeth K. Speliotes,John M. Starr,Kari Stefansson,Kari Stefansson,Valgerdur Steinthorsdottir,Kathleen Stirrups,Kathleen Stirrups,Konstantin Strauch,Heather M. Stringham,Michael Stumvoll,Liang Sun,Liang Sun,Praveen Surendran,Amy J. Swift,Hayato Tada,Hayato Tada,Katherine E. Tansey,Katherine E. Tansey,Jean-Claude Tardif,Kent D. Taylor,Alexander Teumer,Deborah J. Thompson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Betina H. Thuesen,Anke Tönjes,Gerard Tromp,Gerard Tromp,Stella Trompet,Emmanouil Tsafantakis,Jaakko Tuomilehto,Anne Tybjærg-Hansen,Jonathan Tyrer,Rudolf Uher,André G. Uitterlinden,Matti Uusitupa,Sander W. van der Laan,Cornelia M. van Duijn,Nienke van Leeuwen,Nienke van Leeuwen,Jessica van Setten,Mauno Vanhala,Anette Varbo,Tibor V. Varga,Rohit Varma,Digna R. Velez Edwards,Sita H. Vermeulen,Giovanni Veronesi,Henrik Vestergaard,Henrik Vestergaard,Veronique Vitart,Thomas F. Vogt,Uwe Völker,Dragana Vuckovic,Lynne E. Wagenknecht,Mark Walker,Lars Wallentin,Feijie Wang,Carol A. Wang,Shuai Wang,Yiqin Wang,Erin B. Ware,Nicholas J. Wareham,Helen R. Warren,Dawn M. Waterworth,Jennifer Wessel,Harvey D. White,Cristen J. Willer,James G. Wilson,Daniel R. Witte,Andrew R. Wood,Ying Wu,Hanieh Yaghootkar,Jie Yao,Pang Yao,Laura M. Yerges-Armstrong,Laura M. Yerges-Armstrong,Robin Young,Robin Young,Eleftheria Zeggini,Xiaowei Zhan,Weihua Zhang,Weihua Zhang,Jing Hua Zhao,Wei Zhao,Wei Zhao,Wei Zhou,Krina T. Zondervan,Jerome I. Rotter,John Andrew Pospisilik,Fernando Rivadeneira,Ingrid B. Borecki,Panos Deloukas,Panos Deloukas,Timothy M. Frayling,Guillaume Lettre,Kari E. North,Cecilia M. Lindgren,Joel N. Hirschhorn,Joel N. Hirschhorn,Ruth J. F. Loos +489 more
TL;DR: Exome-wide analysis identifies rare and low-frequency coding variants associated with body mass index that confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
Journal ArticleDOI
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci
Chunyu Liu,Aldi T. Kraja,Jennifer A. Smith,Jennifer A. Brody,Nora Franceschini,Joshua C. Bis,Kenneth Rice,Alanna C. Morrison,Yingchang Lu,Stefan Weiss,Xiuqing Guo,Walter Palmas,Lisa W. Martin,Yii-Der Ida Chen,Praveen Surendran,Fotios Drenos,Fotios Drenos,James P. Cook,James P. Cook,Paul L. Auer,Audrey Y. Chu,Ayush Giri,Wei Zhao,Johanna Jakobsdottir,Li-An Lin,Jeanette M. Stafford,Najaf Amin,Hao Mei,Jie Yao,Arend Voorman,Martin G. Larson,Megan L. Grove,Albert V. Smith,Shih-Jen Hwang,Han Chen,Tianxiao Huan,Gulum Kosova,Gulum Kosova,Nathan O. Stitziel,Sekar Kathiresan,Sekar Kathiresan,Nilesh J. Samani,Nilesh J. Samani,Heribert Schunkert,Panos Deloukas,Panos Deloukas,Man Li,Christian Fuchsberger,Cristian Pattaro,Mathias Gorski,Charles Kooperberg,George J. Papanicolaou,Jacques E. Rossouw,Jessica D. Faul,Sharon L.R. Kardia,Claude Bouchard,Leslie J. Raffel,André G. Uitterlinden,Oscar H. Franco,Ramachandran S. Vasan,Christopher J. O'Donnell,Kent D. Taylor,Kiang Liu,Erwin P. Bottinger,Omri Gottesman,E. Warwick Daw,Franco Giulianini,Santhi K. Ganesh,Elias Salfati,Tamara B. Harris,Lenore J. Launer,Marcus Dörr,Stephan B. Felix,Rainer Rettig,Henry Völzke,Eric Kim,Wen-Jane Lee,Wen-Jane Lee,I-Te Lee,Wayne H-H Sheu,Krystal S Tsosie,Digna R. Velez Edwards,Yongmei Liu,Adolfo Correa,David R. Weir,Uwe Völker,Uwe Völker,Paul M. Ridker,Eric Boerwinkle,Vilmundur Gudnason,Alexander P. Reiner,Cornelia M. van Duijn,Ingrid B. Borecki,Todd L. Edwards,Aravinda Chakravarti,Jerome I. Rotter,Bruce M. Psaty,Ruth J. F. Loos,Myriam Fornage,Myriam Fornage,Georg Ehret,Georg Ehret,Christopher Newton-Cheh,Daniel Levy,Daniel Levy,Daniel I. Chasman +105 more
TL;DR: This large collection of blood pressure–associated loci suggests new therapeutic strategies for hypertension, emphasizing a link with cardiometabolic risk.
Journal ArticleDOI
A Tumor-targeting p53 Nanodelivery System Limits Chemoresistance to Temozolomide Prolonging Survival in a Mouse Model of Glioblastoma Multiforme
TL;DR: It is demonstrated that the delivery of exogenous wild-type tumor suppressor gene p53 via a tumor-targeted nanocomplex limited the development of temozolomide resistance and prolonged its anti-tumor effect, which may enable future human application of this or similar techniques.