G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Cell death assays for drug discovery
Oliver Kepp,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Marta M. Lipinski,Junying Yuan,Guido Kroemer,Guido Kroemer +7 more
TL;DR: Approaches to accurately quantify distinct cell death pathways are described, their advantages and pitfalls are discussed, and those techniques that are amenable to HTS are focused on.
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Metabolic control of cell death
TL;DR: The existence of several “metabolic checkpoints” is proposed, refined molecular mechanisms that sense a panel of metabolic variables and emit one or more signals controlling cell fate, which might allow for the development of novel pharmacological approaches that block or stimulate cell death by inducing specific metabolic alterations.
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The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity
Yangchun Xie,Yangchun Xie,Yangchun Xie,Shan Zhu,Xinxin Song,Xiaofang Sun,Yong Fan,Jinbao Liu,Meizuo Zhong,Hua Yuan,Lin Zhang,Timothy R. Billiar,Michael T. Lotze,Herbert J. Zeh,Rui Kang,Guido Kroemer,Daolin Tang,Daolin Tang +17 more
TL;DR: Findings reveal a direct molecular link between TP53 and DPP4 in the control of lipid metabolism and may provide a precision medicine strategy for the treatment of colorectal cancer by induction of ferroptosis.
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Inflammasomes in carcinogenesis and anticancer immune responses
Laurence Zitvogel,Oliver Kepp,Oliver Kepp,Oliver Kepp,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Guido Kroemer +7 more
TL;DR: The inhibition of inflammasomes or neutralization of their products, mainly interleukin 1β (IL-1β) and IL-18, has profound effects on carcinogenesis and tumor progression and is promising therapeutic targets in cancer-related clinical conditions.
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Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death
TL;DR: Several eukaryotes possess a similar domain organisation in their AIF homologs, making them candidates to be mitochondrial oxidoreductases as well as caspase-independent death effectors, and the phylogenetic implications of these findings are discussed.