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Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Journal ArticleDOI
PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor.
Rosa-Ana Gonzalez-Polo,Gabrielle Carvalho,Thorsten Braun,Didier Decaudin,Claire Fabre,Nathanael Larochette,Jean-Luc Perfettini,Mojgan Djavaheri-Mergny,Ibtissam Youlyouz-Marfak,Patrice Codogno,Martine Raphael,Jean Feuillard,Guido Kroemer +12 more
TL;DR: In this paper, a model system was established in which PK11195 and another PBR ligand, 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one (Ro5-4864), sensitize to nutrient depletion-induced cell death.
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Fine-Tuning Cancer Immunotherapy: Optimizing the Gut Microbiome.
Jonathan M. Pitt,Marie Vétizou,Marie Vétizou,Marie Vétizou,Nadine Waldschmitt,Guido Kroemer,Mathias Chamaillard,Ivo G. Boneca,Laurence Zitvogel +8 more
TL;DR: Findings that specific gut-resident bacteria determine the immunotherapeutic responses associated with CTLA-4 checkpoint blockade are presented, and how this new understanding could improve the therapeutic coverage of immune checkpoint inhibitors, and potentially limit their immune-mediated toxicity, through the use of adjunctive "oncomicrobiotics".
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Mitochondrial control of cell death induced by hyperosmotic stress
Alfredo Criollo,Lorenzo Galluzzi,Lorenzo Galluzzi,M. Chiara Maiuri,M. Chiara Maiuri,Ezgi Tasdemir,Ezgi Tasdemir,Sergio Lavandero,Guido Kroemer,Guido Kroemer +9 more
TL;DR: Hyperosmotic stress kills cells by triggering different molecular pathways, which converge at mitochondria where pro- and anti-apoptotic members of the Bcl-2 family exert their control.
Journal ArticleDOI
Megakaryocyte polyploidization is associated with a functional gene amplification
Hana Raslova,Lydia Roy,Lydia Roy,Claire Vourc'h,Claire Vourc'h,Jean Pierre Le Couédic,Jean Pierre Le Couédic,Olivier Brison,Olivier Brison,Didier Métivier,Didier Métivier,Jean Feunteun,Jean Feunteun,Guido Kroemer,Guido Kroemer,Najet Debili,Najet Debili,William Vainchenker,William Vainchenker +18 more
TL;DR: The results demonstrate that megakaryocyte polyploidization results in a functional gene amplification whose likely function is an increase in protein synthesis parallel with cell enlargement.
Journal ArticleDOI
The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species
Didac Carmona-Gutierrez,Andreas Zimmermann,Andreas Zimmermann,Katharina Kainz,Federico Pietrocola,Guo Chen,Silvia Maglioni,Alfonso Schiavi,Jihoon Nah,Sara Mertel,Christine B. Beuschel,Francesca Castoldi,Valentina Sica,Gert Trausinger,Reingard Raml,Cornelia Sommer,Sabrina Schroeder,Sebastian J. Hofer,Maria A. Bauer,Tobias Pendl,Jelena Tadic,Christopher Dammbrueck,Zehan Hu,Christoph Ruckenstuhl,Tobias Eisenberg,Sylvère Durand,Sylvère Durand,Noélie Bossut,Noélie Bossut,Fanny Aprahamian,Fanny Aprahamian,Mahmoud Abdellatif,Simon Sedej,David Enot,David Enot,Heimo Wolinski,Jörn Dengjel,Oliver Kepp,Christoph Magnes,Frank Sinner,Frank Sinner,Thomas R. Pieber,Thomas R. Pieber,Junichi Sadoshima,Natascia Ventura,Stephan J. Sigrist,Stephan J. Sigrist,Guido Kroemer,Frank Madeo +48 more
TL;DR: It is demonstrated that DMC extends lifespan and promotes health in multiple organisms by inducing autophagy and is identified in the plant Angelica keiskei koidzumi, to which longevity- and health-promoting effects are ascribed in Asian traditional medicine.