G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Non‐apoptotic functions of apoptosis‐regulatory proteins
Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Oliver Kepp,Oliver Kepp,Oliver Kepp,Christina Trojel-Hansen,Christina Trojel-Hansen,Christina Trojel-Hansen,Guido Kroemer +9 more
TL;DR: The unconventional roles of the apoptotic core machinery from a functional perspective are summarized and their pathophysiological implications are discussed.
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Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism.
Clea Bárcena,Pedro M. Quirós,Sylvère Durand,Pablo Mayoral,Francisco Rodríguez,Xurde M. Caravia,Guillermo Mariño,Cecilia Garabaya,María Teresa Fernández-García,Guido Kroemer,José M.P. Freije,Carlos López-Otín +11 more
TL;DR: Dietary intervention constitutes a feasible approach for modulating metabolism and improving the health span and lifespan in normal mice and suggests the existence of a metabolic pathway involved in the longevity extension achieved by MR and support the possibility of dietary interventions for treating progeria.
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Trial Watch: DNA vaccines for cancer therapy
Laura Senovilla,Erika Vacchelli,Pauline Garcia,Alexander M.M. Eggermont,Wolf Hervé Fridman,Jérôme Galon,Laurence Zitvogel,Guido Kroemer,Lorenzo Galluzzi +8 more
TL;DR: The latest advances on the use of DNA-based vaccines in cancer therapy are discussed, discussing the literature that has been produced around this topic during the last 13 months as well as clinical studies that have been launched in the same time frame to assess the actual therapeutic potential of this intervention.
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Apoptosis-inducing factor determines the chemoresistance of non-small-cell lung carcinomas.
Miguel-Angel Gallego,Bertrand Joseph,Therese H Hemström,Susan Tamiji,Laurent Mortier,Guido Kroemer,Pierre Formstecher,Boris Zhivotovsky,Philippe Marchetti +8 more
TL;DR: Results indicate that activation of caspases is not sufficient to kill U1810 cells and rather suggests an important role for the AIF-mediated mitochondrial-mediated death pathway, and a transfection-enforced overexpression of AIF did enhance STS-mediated cell killing.
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Targeting p53 to mitochondria for cancer therapy.
TL;DR: Novel approaches of gene therapy have been designed in which p53 is specifically targeted to mitochondria and have been demonstrated to inhibit the growth of human cancer xenografts in immunodeficient mice, suggesting a number of distinct strategies can be employed to achieve the therapeutic induction of MOMP in cancer cells.