G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
Papers
More filters
Journal ArticleDOI
Predictive biomarkers for cancer therapy with PARP inhibitors.
TL;DR: It is surmised that the identification of patients that are likely to benefit from PARP inhibition will improve the clinical use of PARP inhibitors in a defined target population, and special emphasis is placed on biomarker discovery.
Journal ArticleDOI
Simplification of complex peptide mixtures for proteomic analysis: reversible biotinylation of cysteinyl peptides.
Chris Spahr,Santos A. Susin,Edward J. Bures,John H. Robinson,Michael T. Davis,Michael D. McGinley,Guido Kroemer,Scott D. Patterson +7 more
TL;DR: An affinity selection method to capture cysteinyl peptides and thereby simplify the mixture and was applied to the analysis of a protein fraction obtained from isolated mitochondria treated with atractyloside.
Journal ArticleDOI
Caspase-independent commitment phase to apoptosis in activated blood T lymphocytes: reversibility at low apoptotic insult.
Céline Dumont,Antoine Durrbach,Nicolas Bidère,Matthieu Rouleau,Guido Kroemer,Ghislaine Bernard,François Hirsch,Bernard Charpentier,Santos A. Susin,Anna Senik +9 more
TL;DR: A commitment phase to apoptosis was defined that is entirely caspase independent and that is characterized by cell volume loss, partial chromatin condensation, and release into the cytosol and the nucleus of mitochondrial ‘‘apoptosis-inducing factor ’’ (AIF).
Journal ArticleDOI
Autophagy-dependent ATP release from dying cells via lysosomal exocytosis.
TL;DR: It is demonstrated that autophagy allows for the ICD-associated secretion of ATP as it contributes to the maintenance of lysosomal ATP stores, and it is found that ATP release in this setting is mediated by a molecular mechanism that involves lYSosomal-associated membrane protein 1 (LAMP1)- and pannexin 1 (PANX1)-dependent lysOSomal exocytosis.
Journal ArticleDOI
Aspirin Recapitulates Features of Caloric Restriction.
Federico Pietrocola,Francesca Castoldi,Maria Markaki,Sylvie Lachkar,Guo Chen,David Enot,Sylvère Durand,Noélie Bossut,Mingming Tong,Shoaib Ahmad Malik,Friedemann Loos,Nicolas Dupont,Guillermo Mariño,Nejma Abdelkader,Frank Madeo,Maria Chiara Maiuri,Romano T. Kroemer,Patrice Codogno,Junichi Sadoshima,Nektarios Tavernarakis,Guido Kroemer +20 more
TL;DR: It is shown that aspirin or its active metabolite salicylate induce autophagy by virtue of their capacity to inhibit the acetyltransferase activity of EP300, and this findings identify aspirin as an evolutionary conserved CRM.