G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Journal ArticleDOI
Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy
Heng Yang,Yuting Ma,Guo Chen,Heng Zhou,Takahiro Yamazaki,Christophe Klein,Federico Pietrocola,Erika Vacchelli,Sylvie Souquere,Allan Sauvat,Laurence Zitvogel,Oliver Kepp,Guido Kroemer +12 more
TL;DR: It is suggested that RIP3 and MLKL can contribute to ICD signaling and tumor immunogenicity.
Journal ArticleDOI
Functional Mitochondria Are Required for α-Synuclein Toxicity in Aging Yeast
Sabrina Büttner,Alessandro Bitto,Julia Ring,Manuela Augsten,Piotr Zabrocki,Tobias Eisenberg,Helmut Jungwirth,Sylvia Hutter,Didac Carmona-Gutierrez,Guido Kroemer,Guido Kroemer,Joris Winderickx,Frank Madeo +12 more
TL;DR: It is demonstrated that abrogation of mitochondrial DNA (rho0) inhibited α-synuclein-induced reactive oxygen species formation and subsequent apoptotic cell death, and a strict requirement of functional mitochondria was demonstrated.
Journal ArticleDOI
Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade
Nicolas Jacquelot,Takahiro Yamazaki,Maria Paula Roberti,Connie P.M. Duong,Miles C. Andrews,Miles C. Andrews,Loic Verlingue,Loic Verlingue,Gladys Ferrere,Sonia Becharef,Marie Vétizou,Romain Daillère,Meriem Messaoudene,David Enot,Gautier Stoll,Stefano Ugel,Ilaria Marigo,Shin Foong Ngiow,Shin Foong Ngiow,Aurélien Marabelle,Aurélien Marabelle,Armelle Prévost-Blondel,Armelle Prévost-Blondel,Armelle Prévost-Blondel,Pierre Olivier Gaudreau,Vancheswaran Gopalakrishnan,Alexander M.M. Eggermont,Paule Opolon,Christophe Klein,Gabriele Madonna,Paolo A. Ascierto,Antje Sucker,Dirk Schadendorf,Mark J. Smyth,Mark J. Smyth,Jean-Charles Soria,Guido Kroemer,Vincenzo Bronte,Jennifer A. Wargo,Laurence Zitvogel +39 more
TL;DR: The deleterious role of signaling via the type I interferon (IFN) receptor in tumor and antigen presenting cells, that induced the expression of nitric oxide synthase 2 (NOS2), associated with intratumor accumulation of regulatory T cells and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody (mAb), is identified.
Journal ArticleDOI
Apoptosis-inducing factor mediates microglial and neuronal apoptosis caused by pneumococcus.
Johann S. Braun,Rodger Novak,Peter J. Murray,Christine M. Eischen,Santos A. Susin,Guido Kroemer,Annett Halle,Joerg R. Weber,Elaine Tuomanen,John L. Cleveland,John L. Cleveland +10 more
TL;DR: It is shown that AIF may play a central role in brain cell apoptosis and bacterial pathogenesis, and intracytoplasmatic microinjection of AIF-specific antiserum markedly impaired pneumococcus-induced apoptosis.
Book ChapterDOI
Immune response against dying tumor cells.
Laurence Zitvogel,Noelia Casares,Marie O. Pequignot,Nathalie Chaput,Matthew L. Albert,Guido Kroemer +5 more
TL;DR: This chapter examines the way the modality of tumor cell death and/or the immune system can be manipulated so dying tumor cells become immunogenic and clear evidence in favor of tumor escape mechanisms is provided.