G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Journal ArticleDOI
Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia.
Changlian Zhu,Xiaoyang Wang,Xiaoyang Wang,Zhiheng Huang,Zhiheng Huang,Lin Qiu,Lin Qiu,Falin Xu,Falin Xu,N. Vahsen,Michael Nilsson,Peter S. Eriksson,Henrik Hagberg,Henrik Hagberg,Carsten Culmsee,Nikolaus Plesnila,Guido Kroemer,Klas Blomgren,Klas Blomgren +18 more
TL;DR: Two distinct strategies can enhance the neuroprotection conferred by the Hq mutation, antioxidants, presumably compensating for a defect in AIF-dependent redox detoxification, and caspase inhibitors, presumably interrupting a parallel pathway leading to cellular demise.
Journal ArticleDOI
Organelle-specific initiation of cell death
Lorenzo Galluzzi,Lorenzo Galluzzi,José Manuel Bravo-San Pedro,José Manuel Bravo-San Pedro,Guido Kroemer +4 more
TL;DR: The mechanisms whereby cellular compartments sense homeostatic perturbations and translate them into a cell-death-initiating signal are discussed, which can respond to stress by attemptinwg to recover homeostasis or by activating molecular cascades that lead to cell death by apoptosis or necrosis.
Journal ArticleDOI
Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics.
Abhishek D. Garg,Sanket More,Nicole Rufo,Odeta Mece,Maria Livia Sassano,Patrizia Agostinis,Laurence Zitvogel,Guido Kroemer,Lorenzo Galluzzi,Lorenzo Galluzzi +9 more
TL;DR: Recent progress on the development of ICD-inducing chemotherapeutic regimens is discussed, focusing on studies that evaluate clinical efficacy in conjunction with immunological biomarkers.
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Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol.
Eugenia Morselli,Lorenzo Galluzzi,Oliver Kepp,Alfredo Criollo,Maria Chiara Maiuri,Nektarios Tavernarakis,Frank Madeo,Guido Kroemer +7 more
TL;DR: Results point to an essential role of protein hypoacetylation in autophagy control and in the regulation of longevity.
Journal ArticleDOI
Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death.
Nicolas Tajeddine,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Oliver Kepp,Oliver Kepp,Oliver Kepp,Emilie Hangen,Emilie Hangen,Emilie Hangen,Eugenia Morselli,Eugenia Morselli,Eugenia Morselli,Laura Senovilla,Laura Senovilla,Laura Senovilla,Natalia Araujo,Natalia Araujo,Guillaume Pinna,Guillaume Pinna,Nathanael Larochette,Naoufal Zamzami,Naoufal Zamzami,Naoufal Zamzami,Nazanine Modjtahedi,Nazanine Modjtahedi,Nazanine Modjtahedi,Annick Harel-Bellan,Annick Harel-Bellan,Guido Kroemer,Guido Kroemer,Guido Kroemer +31 more
TL;DR: A novel pathway for the induction of mitochondrial membrane permeabilization (MMP) in the course of CDDP-induced cell death that involves a hierarchical contribution of Bak, VDAC1 and Bax is delineated, suggesting that VD AC1 may act as a facultative regulator/effector of MMP, depending on the initial cytotoxic event.