Guido Kroemer

TL;DR: It is shown that pheromones can act as physiological inducers of CRT Exposure in yeast cells, thereby facilitating the formation of mating conjugates, and that a large-spectrum inhibitor of G protein-coupled receptors prevents CRT exposure in human cancer cells exposed to MTX.

TL;DR: In this paper, the effects of the bona fide Aurora-B kinase inhibitor AZD1152 on tumor responses to ionizing radiation (IR) were evaluated in vitro and in vivo.

TL;DR: In this article, the effects of rapamycin on the mTOR signaling pathway, cell cycle control and apoptosis were studied before and after drug exposure by RT-PCR, and the results indicated that baseline Bcl-2 expression and therapy-induced downexpression of CCND1 and CDK4 may be regarded as molecular markers enabling the prediction and follow-up of the cellular effects on cell cycle.

TL;DR: Results point to the capacity of redaporfin to kill tumor cells via destroying ER/GA function through the inhibition of protein secretion by PDT‐treated cancer cells.

TL;DR: Clinical findings that have been published during the last 13 months as well as clinical trials that have be launched in the same period to investigate the therapeutic profile of hitherto investigational tumor-targeting mAbs are discussed.