G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.
Martin A. Bewley,Helen M. Marriott,Calogero Tulone,Sheila E. Francis,Timothy J. Mitchell,Robert C. Read,Benny Chain,Guido Kroemer,Moira K. B. Whyte,David H. Dockrell +9 more
TL;DR: It is shown that lysosomal membrane permeabilization (LMP) and cytosolic translocation of activated cathepsin D occur prior to activation of a mitochondrial pathway of macrophage apoptosis in pulmonary host defense and underscores the importance of apoptosis-associated microbial killing to macrophages function.
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Critical Involvement of Extracellular ATP Acting on P2RX7 Purinergic Receptors in Photoreceptor Cell Death
Shoji Notomi,Toshio Hisatomi,Takaaki Kanemaru,Atsunobu Takeda,Yasuhiro Ikeda,Hiroshi Enaida,Guido Kroemer,Tatsuro Ishibashi +7 more
TL;DR: The results encourage the potential application of Brilliant Blue G as a novel neuroprotective agent in retinal diseases or similar neurodegenerative pathologies linked to excessive extracellular ATP.
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Caspase activation is not death.
TL;DR: Caspase inhibition can actually encourage death in tumor necrosis factor–induced shock, indicating that caspase activation is not synonymous with apoptotic demise.
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Oxaliplatin-induced mitochondrial apoptotic response of colon carcinoma cells does not require nuclear DNA.
TL;DR: Data demonstrate that oxaliplatin exerts its cytotoxic effects by inducing mitochondrial apoptosis and that these effects can be initiated by interacting on other cellular structures than nuclear DNA.
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Cell-Surface-Expressed HIV-1 Envelope Induces the Death of CD4 T Cells during GP41-Mediated Hemifusion-like Events
Julià Blanco,Jordi Barretina,Karine F. Ferri,Etienne Daniel Jacotot,Arantxa Gutiérrez,Mercedes Armand-Ugón,Cecilia Cabrera,Guido Kroemer,Bonaventura Clotet,José A. Esté +9 more
TL;DR: It is concluded that after gp120 function, gp41 mediates close cell-to-cell contacts, thereby triggering cell death in single uninfected cells in the absence of detectable cell- to-cell fusion.