G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Targeting autophagy as a novel strategy for facilitating the therapeutic action of potentiators on ΔF508 cystic fibrosis transmembrane conductance regulator.
Alessandro Luciani,Valeria Rachela Villella,Speranza Esposito,Manuela Gavina,Ilaria Russo,Marco Silano,Stefano Guido,Massimo Pettoello-Mantovani,Rosa Carnuccio,Bob J. Scholte,Antonella De Matteis,Maria Chiara Maiuri,Valeria Raia,Alberto Luini,Guido Kroemer,Luigi Maiuri +15 more
TL;DR: It is demonstrated that human and mouse CF airways are autophagy deficient due to functional sequestration of BECN1 and that the tissue transglutaminase-2 inhibitor, cystamine, or antioxidants restore BECn1-dependent autophamy and reduce SQSTM1/p62 levels, thus favoring ΔF508-CFTR trafficking to the epithelial surface.
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Immune responses during COVID-19 infection
Cléa Melenotte,Aymeric Silvin,Anne Gaëlle Goubet,Imran Lahmar,Agathe Dubuisson,Alimuddin Zumla,Didier Raoult,Didier Raoult,Mansouria Merad,Bertrand Gachot,Clémence Hénon,Eric Solary,Michaela Fontenay,Fabrice Andre,Markus Maeurer,Giuseppe Ippolito,Mauro Piacentini,Fu-Sheng Wang,Florent Ginhoux,Florent Ginhoux,Florent Ginhoux,Aurélien Marabelle,Guido Kroemer,Lisa Derosa,Laurence Zitvogel +24 more
TL;DR: In innate and cognate immune responses underlying protective or deleterious immune reactions against these pathogenic coronaviruses are discussed, including immune responses to SARS-CoV2.
Journal Article
Proteasome Activation Occurs at an Early, Premitochondrial Step of Thymocyte Apoptosis
Tamara Hirsch,Bruno Dallaporta,Naoufal Zamzami,Santos A. Susin,Luigi Ravagnan,Isabel Marzo,Catherine Brenner,Guido Kroemer +7 more
TL;DR: It is shown that inhibition of proteasomes by two specific agents, lactacystin or MG132, prevents all manifestations of thymocyte apoptosis induced by the glucocorticoid receptor agonist dexamethasone or by the topoisomerase II inhibitor etoposide.
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Mitochondrial release of apoptosis-inducing factor and cytochrome c during smooth muscle cell apoptosis.
David J. Granville,Brighid A. Cassidy,Dietrich O. Ruehlmann,Jonathan C. Choy,Catherine Brenner,Guido Kroemer,Cornelis van Breemen,Philippe Margaron,David W. C. Hunt,Bruce M. McManus +9 more
TL;DR: These results demonstrate for the first time the cellular redistribution of mitochondrial AIF during SMC apoptosis, as well as the early release of cyt c and the subsequent activation of multiple caspases during PDT-induced SMCs apoptosis.
Journal ArticleDOI
The Molecular Hallmarks of the Serrated Pathway in Colorectal Cancer
Fatima Domenica Elisa De Palma,Valeria D'Argenio,Jonathan Pol,Jonathan Pol,Guido Kroemer,Maria Chiara Maiuri,Maria Chiara Maiuri,Francesco Salvatore +7 more
TL;DR: This review summarizes the state of the art of the genetic, epigenetic and microbiota signatures associated with serrated CRCs, together with their clinical implications.