G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Mitochondrial Permeability Transition: New Findings and Persisting Uncertainties.
TL;DR: This work summarizes recent findings shedding new light on the supramolecular entity that mediates MPT, the so-called 'permeability transition pore complex' (PTPC), and discusses hitherto unresolved controversies on MPT.
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Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles
Massimo Bonora,Mariusz R. Wieckowski,David A. Sinclair,Guido Kroemer,Paolo Pinton,Lorenzo Galluzzi +5 more
TL;DR: The therapeutic potential of targeting mitochondria in patients with cardiovascular disease is discussed, the obstacles that have restrained the development of mitochondria-targeting agents thus far are examined, and strategies that might empower the full clinical potential of this approach are identified.
Journal Article
Peripheral Benzodiazepine Receptor Ligands Reverse Apoptosis Resistance of Cancer Cells in Vitro and in Vivo
Didier Decaudin,Maria Castedo,Fariba Nemati,Arnaud Beurdeley-Thomas,Gonzague de Pinieux,Antoine Caron,Pierre Pouillart,John Wijdenes,Dany Rouillard,Guido Kroemer,Marie-France Poupon +10 more
TL;DR: In vivo, the RO5-4864 mPBR ligand significantly increased the growth inhibition induced by two chemotherapeutic agents, etoposide and ifosfamide, using two human small cell lung cancers xenografted into nude mice.
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Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection
Claire Séror,Marie Thérèse Melki,Frédéric Subra,Syed Qasim Raza,Syed Qasim Raza,Marlène Bras,Héla Saïdi,Roberta Nardacci,Laurent Voisin,Laurent Voisin,Audrey Paoletti,Audrey Paoletti,Frédéric Law,Frédéric Law,Isabelle Martins,Isabelle Martins,Alessandra Amendola,Ali A. Abdul-Sater,Fabiola Ciccosanti,Olivier Delelis,Florence Niedergang,Florence Niedergang,Florence Niedergang,Sylvain Thierry,Najwane Said-Sadier,Christophe Lamaze,Didier Métivier,Didier Métivier,Jérôme Estaquier,Jérôme Estaquier,Gian Maria Fimia,Laura Falasca,Rita Casetti,Nazanine Modjtahedi,Nazanine Modjtahedi,Jean Kanellopoulos,Jean-François Mouscadet,David M. Ojcius,David M. Ojcius,Mauro Piacentini,Marie-Lise Gougeon,Guido Kroemer,Jean-Luc Perfettini,Jean-Luc Perfettini +43 more
TL;DR: Contact with HIV-1 envelope protein elicits release of ATP through pannexin-1 channels on target cells; by activating purinergic receptors and Pyk2 kinase in target cells, this extracellular ATP boosts HIV- 1 infectivity.
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Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity
Heng Yang,Lin Xia,Jian Chen,Shuqing Zhang,Vincent Martin,Qingqing Li,Shangqing Lin,Jinfeng Chen,Joseph Calmette,Min Lu,Fu Lingyi,Jie Yang,Zhizhong Pan,Kuai Yu,Jingjing He,Eric F Morand,Géraldine Schlecht-Louf,Roman Krzysiek,Laurence Zitvogel,Boxi Kang,Zeming Zhang,Andrew Leader,Penghui Zhou,Laurence Lanfumey,Minxin Shi,Guido Kroemer,Yuting Ma +26 more
TL;DR: Results indicate that stress-induced glucocorticoid surge and Tsc22d3 upregulation can subvert therapy-induced anticancer immunosurveillance.