G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Journal ArticleDOI
Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process
Santos A. Susin,Hans K. Lorenzo,Naoufal Zamzami,Isabel Marzo,Catherine Brenner,Nathanael Larochette,Marie-Christine Prévost,Pedro M. Alzari,Guido Kroemer +8 more
TL;DR: The data suggest that caspase-2 and -9 zymogens are essentially localized in mitochondria and that the disruption of the outer mitochondrial membrane occurring early during apoptosis may be critical for their subcellular redistribution and activation.
Journal ArticleDOI
Mitochondrial metabolism and cancer.
Paolo E. Porporato,Nicoletta Filigheddu,José Manuel Bravo-San Pedro,Guido Kroemer,Lorenzo Galluzzi,Lorenzo Galluzzi +5 more
TL;DR: The cancer cell-intrinsic and cell-extrinsics mechanisms through which mitochondria influence all steps of oncogenesis are reviewed, with a focus on the therapeutic potential of targeting mitochondrial metabolism for cancer therapy.
Autophagy-Inflammation-Cell Death Axis in Organismal Aging
TL;DR: A combination of mitochondrial dysfunction and insufficient autophagy may contribute to multiple aging-associated pathologies.
Journal ArticleDOI
Cardioprotection and lifespan extension by the natural polyamine spermidine
Tobias Eisenberg,Mahmoud Abdellatif,Sabrina Schroeder,Uwe Primessnig,Uwe Primessnig,Slaven Stekovic,Tobias Pendl,Alexandra Harger,Alexandra Harger,Julia Schipke,Andreas Zimmermann,Albrecht Schmidt,Mingming Tong,Christoph Ruckenstuhl,Christopher Dammbrueck,Angelina S. Gross,Viktoria Herbst,Christoph Magnes,Gert Trausinger,Sophie H. Narath,Andreas Meinitzer,Zehan Hu,Zehan Hu,Alexander H. Kirsch,Kathrin Eller,Didac Carmona-Gutierrez,Sabrina Büttner,Sabrina Büttner,Federico Pietrocola,Oskar Knittelfelder,Emilie Schrepfer,Patrick Rockenfeller,Patrick Rockenfeller,Corinna Simonini,Alexandros Rahn,Marion Horsch,Kristin Moreth,Johannes Beckers,Helmut Fuchs,Valerie Gailus-Durner,Frauke Neff,Dirk Janik,Birgit Rathkolb,Jan Rozman,Martin Hrabé de Angelis,Tarek Moustafa,Tarek Moustafa,Guenter Haemmerle,Manuel Mayr,Peter Willeit,Peter Willeit,Marion von Frieling-Salewsky,Burkert Pieske,Burkert Pieske,Luca Scorrano,Thomas R. Pieber,Thomas R. Pieber,Raimund Pechlaner,Johann Willeit,Stephan J. Sigrist,Stephan J. Sigrist,Wolfgang A. Linke,Christian Mühlfeld,Junichi Sadoshima,Joern Dengjel,Joern Dengjel,Stefan Kiechl,Guido Kroemer,Simon Sedej,Frank Madeo +69 more
TL;DR: It is shown that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice, and suggests a new and feasible strategy for protection against cardiovascular disease.
Journal ArticleDOI
Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance.
TL;DR: The capacity of both conventional and targeted anticancer therapies to enhance the immunogenic properties of malignant cells and to stimulate immune effector cells, either directly or by subverting the immunosuppressive circuitries that preclude antitumor immune responses in cancer patients are discussed.