G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Journal ArticleDOI
Premortem autophagy determines the immunogenicity of chemotherapy-induced cancer cell death
Isabelle Martins,Mickaël Michaud,Abdul Qader Sukkurwala,Sandy Adjemian,Yuting Ma,Shensi Shen,Oliver Kepp,Laurie Menger,Erika Vacchelli,Lorenzo Galluzzi,Laurence Zitvogel,Guido Kroemer +11 more
TL;DR: Results suggest that autophagy-incompetent tumor cells escape from chemotherapy-induced (and perhaps natural?) immunosurveillance because they are unable to release ATP.
Journal ArticleDOI
Oncosuppressive functions of autophagy.
Eugenia Morselli,Lorenzo Galluzzi,Oliver Kepp,Guillermo Mariño,Mickaël Michaud,Ilio Vitale,Maria Chiara Maiuri,Guido Kroemer +7 more
TL;DR: Several oncosuppressor proteins and oncoproteins have been recently shown to stimulate and inhibit the autophagic flow, respectively, suggesting that autophagy exerts bona fide tumor-suppressive functions.
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MaBoSS 2.0: an environment for stochastic Boolean modeling.
Gautier Stoll,Barthélémy Caron,Eric Viara,Aurelien Dugourd,Andrei Zinovyev,Aurélien Naldi,Guido Kroemer,Emmanuel Barillot,Laurence Calzone +8 more
TL;DR: A new version of MaBoSS (2.0) is presented, including an updated version of the core software and an environment, which offers a framework for automated production of theoretical predictions.
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Dynamic evolution of the adenine nucleotide translocase interactome during chemotherapy-induced apoptosis
Florence Verrier,Aurélien Deniaud,Morgane LeBras,Didier Métivier,Guido Kroemer,Bernard Mignotte,Gwénaël Jan,Catherine Brenner +7 more
TL;DR: Changes within this ANT interactome coordinate the lethal response of cells to apoptosis induction, suggesting that GST behaves as an endogenous repressor of PTPC and ANT pore opening.
Journal Article
Enhancement of radiation response in p53 deficient cancer cells by the Aurora-B kinase inhibitor AZD1152
TL;DR: Data indicate that AZD1152 can radiosensitize tumor cell lines in vitro and in vivo, and the fact that these effects are exacerbated in p53-deficient cancer cells is of potential interest for further clinical development.