G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Journal ArticleDOI
Physical interaction of apoptosis-inducing factor with DNA and RNA
Nicola Vahsen,Céline Candé,Pauline Dupaigne,Fabrizio Giordanetto,Romano T. Kroemer,E Herker,S Scholz,Nazanine Modjtahedi,Frank Madeo,E Le Cam,Guido Kroemer +10 more
TL;DR: The AIF interactome, as determined by mass spectroscopy, contains a large panel of ribonucleoproteins, which apparently bind to AIF through the RNA moiety, and these data support a model in which a direct interaction of AIF contributes to the compaction of nucleic acids within apoptotic cells.
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Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors.
Jonathan Pol,Sarah Levesque,Samuel T Workenhe,Shashi Gujar,Fabrice Le Boeuf,Fabrice Le Boeuf,Derek R. Clements,Jean-Eudes Fahrner,Jean-Eudes Fahrner,Laetitia Fend,John C. Bell,John C. Bell,Karen L. Mossman,Jitka Fucikova,Radek Spisek,Laurence Zitvogel,Laurence Zitvogel,Guido Kroemer,Lorenzo Galluzzi,Lorenzo Galluzzi +19 more
TL;DR: Recent preclinical and clinical progress in the field of oncolytic virotherapy is summarized to support the establishment of therapeutically relevant tumor-specific immune responses.
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Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity
Yi Huang,Huanyu Wang,Yize Hao,Hualong Lin,Menghao Dong,Menghao Dong,Jin Ye,Lei Song,Yunzhi Wang,Qingqing Li,Benjie Shan,Yi-Zhou Jiang,Hongqi Li,Zhiming Shao,Guido Kroemer,Huafeng Zhang,Li Bai,Tengchuan Jin,Chao Wang,Yuting Ma,Yongping Cai,Chen Ding,Suling Liu,Yueyin Pan,Wei Jiang,Rongbin Zhou +25 more
TL;DR: It is shown that, in response to chemotherapy, PTEN directly interacts with NLRP3 in myeloid cells to enhance inflammasome activation and antitumour immune responses.
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Subversion of the chemotherapy-induced anticancer immune response by the ecto-ATPase CD39
Mickaël Michaud,Abdul Qader Sukkurwala,Isabelle Martins,Shensi Shen,Laurence Zitvogel,Guido Kroemer +5 more
TL;DR: It is observed that overexpression of CD39, an ATP-degrading enzyme expressed on the cell surface, abolishes the immunogenicity of cell death, thus rendering cancers resistant against chemotherapy.
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Trial Watch: Adoptively transferred cells for anticancer immunotherapy
Carole Fournier,François Martin,François Martin,Laurence Zitvogel,Guido Kroemer,Lorenzo Galluzzi,Lorenzo Galluzzi,Lionel Apetoh,Lionel Apetoh +8 more
TL;DR: Recent clinical advances on the use of adoptive cell transfer (ACT) for oncological indications are summarized in this Trial Watch.