G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
Papers
More filters
Journal ArticleDOI
Mitophagy: An Emerging Role in Aging and Age-Associated Diseases.
TL;DR: There is increasing evidence that mitophagy is significantly impaired in several human pathologies including aging and age-related diseases such as neurodegenerative disorders, cardiovascular pathologies and cancer and therapeutic interventions aiming at the induction of mitophile may have the potency to ameliorate these dysfunctions.
Journal ArticleDOI
Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling.
A. Ko,Kanehisa A,Kanehisa A,Isabelle Martins,Isabelle Martins,Laura Senovilla,Laura Senovilla,Cyrus Chargari,Cyrus Chargari,Delphine Dugue,Guillermo Mariño,Guillermo Mariño,Oliver Kepp,Oliver Kepp,Mickaël Michaud,Mickaël Michaud,Jean-Luc Perfettini,Jean-Luc Perfettini,Guido Kroemer,Eric Deutsch +19 more
TL;DR: The results reveal that beyond its cytoprotective function, autophagy confers immunogenic properties to tumours, hence amplifying the efficacy of radiotherapy in an immunocompetent context, and has far-reaching implications for the development of pharmacological radiosensitizers.
Journal ArticleDOI
Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8 + T cells
Martin Uhl,Oliver Kepp,Oliver Kepp,Oliver Kepp,Hélène Jusforgues-Saklani,Hélène Jusforgues-Saklani,Jose Miguel Vicencio,Jose Miguel Vicencio,Jose Miguel Vicencio,Guido Kroemer,Guido Kroemer,Guido Kroemer,Albert Ml,Albert Ml,Albert Ml +14 more
TL;DR: It is predicted that targeting the autophagy cascade may provide a therapeutic strategy for achieving robust cross-priming of viral and tumor-specific CD8+ T cells.
Journal ArticleDOI
Trial Watch: Experimental Toll-like receptor agonists for cancer therapy.
Lorenzo Galluzzi,Erika Vacchelli,Alexander M.M. Eggermont,Wolf Hervé Fridman,Jérôme Galon,Catherine Sautès-Fridman,Eric Tartour,Laurence Zitvogel,Guido Kroemer +8 more
TL;DR: The role of TLRs in innate and cognate immunity is presented and the progress of clinical studies evaluating the safety and efficacy of experimental TLR agonists as immunostimulatory agents for oncological indications is discussed.
Journal ArticleDOI
Why yeast cells can undergo apoptosis: death in times of peace, love, and war
Sabrina Büttner,Tobias Eisenberg,Eva Herker,Didac Carmona-Gutierrez,Guido Kroemer,Frank Madeo +5 more
TL;DR: Yeast apoptosis during aging, mating, or exposure to killer toxins is described, underscoring the evolutionary benefit of a cell suicide program in yeast and, thus, giving a unicellular organism causes to die for.