G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Mitochondrial permeability transition involves dissociation of F1FO ATP synthase dimers and C-ring conformation
Massimo Bonora,Claudia Morganti,Giampaolo Morciano,Gaia Pedriali,Magdalena Lebiedzinska-Arciszewska,Giorgio Aquila,Carlotta Giorgi,Paola Rizzo,Gianluca Campo,Roberto Ferrari,Guido Kroemer,Mariusz R. Wieckowski,Lorenzo Galluzzi,Paolo Pinton +13 more
TL;DR: It is demonstrated that F1FO ATP synthase dimers dissociate as the PTPC opens upon MPT induction and involves the C‐ring, and it is revealed that PTPC opening requires the dissociation of F1 FO ATP synthases dimers.
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Genetic analysis of the mammalian cell death machinery
TL;DR: Recent insights into the cellular death program as revealed by mice are discussed, including inactivation of genes involved in cell death using homologous recombination.
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Mitochondrial dysfunctions in circulating T lymphocytes from human immunodeficiency virus-1 carriers.
Antonio Macho,Maria Castedo,Philippe Marchetti,José J. Aguilar,Didier Decaudin,Naoufal Zamzami,Pierre Girard,José Uriel,Guido Kroemer +8 more
TL;DR: The extent of delta psi m reduction, as determined ex vivo, correlates with the frequency of cells undergoing DNA fragmentation after overnight in vitro culture, which may be important for the understanding and for the direct ex vivo quantitation of HIV-triggered lymphocyte destruction.
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Targeting NF-κB in hematologic malignancies
TL;DR: NF-κB inhibitory molecules may be clinically useful, either as single therapeutic agents or in combination with classical chemotherapeutic agents, for the treatment of hematological malignancies.
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Human Immunodeficiency Virus 1 Envelope Glycoprotein Complex-Induced Apoptosis Involves Mammalian Target of Rapamycin/Fkbp12-Rapamycin–Associated Protein–Mediated P53 Phosphorylation
Maria Castedo,Karine F. Ferri,Julià Blanco,Thomas Roumier,Nathanael Larochette,Jordi Barretina,Alessandra Amendola,Roberta Nardacci,Didier Métivier,José A. Esté,Mauro Piacentini,Guido Kroemer +11 more
TL;DR: It is demonstrated that phosphorylation of p53S15 by mTOR/FRAP plays a critical role in syncytial apoptosis driven by HIV-1 Env, as well as in peripheral blood mononuclear cells, correlating with viral load.