Guido Kroemer

TL;DR: It is shown that the inhibition of TG2 restores the unbalance in HSF1‐HSP70 pathway in cystic fibrosis (CF), a human disorder characterized by deregulation of proteostasis through the modulation of the heat‐shock response.

TL;DR: HIV-1 GPX possesses a cytoprotective, pathophysiologically relevant function, and clinical HIV-1 isolates from long-term non-progressors mostly possess an intact GPX gene, while patients developing AIDS contain non-functional GPX mutants.

TL;DR: The results support the idea that intracellular α-ketoglutarate inhibits starvation-induced autophagy and that it has no direct respiration-inhibitory effect.

TL;DR: In this article, an oncogenic mutant form of NPM1 (NPM1c) impairs mitochondrial function and hampers formation of PML nuclear bodies, which are regulators of mitochondrial fitness and key senescence effectors.

TL;DR: In this paper, the authors found that malignant disease favors the magnitude and duration of viral RNA shedding concomitant with prolonged serum elevations of type 1 IFN that anticorrelated with anti-RBD IgG antibodies, and that low lymphocyte counts correlated with chronic SARS-CoV-2 RNA shedding, COVID-19 severity, and a higher risk of cancer-related death in the first and second surge of the pandemic.