G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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An AIF orthologue regulates apoptosis in yeast
Silke Wissing,Paula Ludovico,Eva Herker,Sabrina Büttner,Silvia Engelhardt,Thorsten Decker,Alexander Link,Astrid Proksch,Fernando Rodrigues,Manuela Côrte-Real,Kai-Uwe Fröhlich,Joachim Manns,Céline Candé,Stephen J. Sigrist,Guido Kroemer,Frank Madeo +15 more
TL;DR: It is shown that the yeast AIF homologue Ynr074cp controls yeast apoptosis and is renamed AIF-1 (Aif1p, gene AIF1), a cell death effector in yeast, which is essential for normal mammalian development and participates in pathological apoptosis.
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Dendritic cell-derived exosomes for cancer therapy
Jonathan M. Pitt,Jonathan M. Pitt,Fabrice Andre,Fabrice Andre,Sebastian Amigorena,Jean-Charles Soria,Alexander M.M. Eggermont,Guido Kroemer,Laurence Zitvogel +8 more
TL;DR: This Review will evaluate the interactions of Dex with immune cells, their clinical progress, and the future of Dex immunotherapy for cancer.
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AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc- Activity.
Xinxin Song,Xinxin Song,Shan Zhu,Pan Chen,Wen Hou,Qirong Wen,Jiao Liu,Yangchun Xie,Yangchun Xie,Jinbao Liu,Daniel J. Klionsky,Guido Kroemer,Michael T. Lotze,Herbert J. Zeh,Rui Kang,Daolin Tang,Daolin Tang +16 more
TL;DR: It is shown that BECN1 plays a hitherto unsuspected role in promoting ferroptosis through directly blocking system Xc- activity via binding to its core component, SLC7A11 (solute carrier family 7 member 11).
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Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance
Federico Pietrocola,Federico Pietrocola,Jonathan Pol,Erika Vacchelli,Erika Vacchelli,Shuan Rao,David Enot,Elisa E. Baracco,Sarah Levesque,Francesca Castoldi,Nicolas Jacquelot,Takahiro Yamazaki,Laura Senovilla,Guillermo Mariño,Guillermo Mariño,Fernando Aranda,Fernando Aranda,Sylvère Durand,Valentina Sica,Alexis Chery,Sylvie Lachkar,Verena Sigl,Norma Bloy,Aitziber Buqué,Simonetta Falzoni,Bernhard Ryffel,Bernhard Ryffel,Lionel Apetoh,Lionel Apetoh,Francesco Di Virgilio,Frank Madeo,Maria Chiara Maiuri,Laurence Zitvogel,Beth Levine,Josef M. Penninger,Guido Kroemer +35 more
TL;DR: Short-term fasting or treatment with several chemically unrelated autophagy-inducing CRMs, including hydroxycitrate and spermidine, improved the inhibition of tumor growth by chemotherapy in vivo and improved anticancer immunosurveillance and reducing tumor mass.
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Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine
Patricia Boya,Rosa-Ana Gonzalez-Polo,Delphine Poncet,Karine Andreau,Helena L. A. Vieira,Thomas Roumier,Jean-Luc Perfettini,Guido Kroemer +7 more
TL;DR: It is shown that hydroxychloroquine induces signs of lysosomal membrane permeabilization (LMP), and that Bax/Bak-dependent MMP is a critical step of LMP-induced cell death.