G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Mitochondrion-mediated apoptosis in HIV-1 infection.
TL;DR: It appears that the pathogenesis of AIDS, and the pharmacological interventions and complications associated with this disease, affect the mitochondrial regulation of apoptosis, which, therefore, largely determines the outcome of HIV-1 infection.
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Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy.
Mireia Niso-Santano,Shensi Shen,Sandy Adjemian,Shoaib Ahmad Malik,Guillermo Mariño,Sylvie Lachkar,Laura Senovilla,Oliver Kepp,Lorenzo Galluzzi,Maria Chiara Maiuri,Guido Kroemer +10 more
TL;DR: An unsuspected crosstalk between cellular metabolism (fatty acids), pro-inflammatory signaling (STAT3), innate immunity (EIF2AK2), and translational control (Eif2S1) that regulates autophagy is revealed.
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Clinical evidence that immunogenic cell death sensitizes to PD-1/PD-L1 blockade.
TL;DR: Findings support the translational utility of the concept of ICD by confirming that pretreatment with ICD-inducing anthracyclines sensitizes to immune checkpoint blockade targeting PD-1 and PD-L1 interaction.
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AIF-regulated oxidative phosphorylation supports lung cancer development
Shuan Rao,Shuan Rao,Laura Mondragón,Blanka Pranjic,Toshikatsu Hanada,Gautier Stoll,Thomas Köcher,Peng Zhang,Alexander Jais,Alexander Lercher,Andreas Bergthaler,Daniel Schramek,Katharina Haigh,Katharina Haigh,Valentina Sica,Marion Leduc,Nazanine Modjtahedi,Nazanine Modjtahedi,Tsung-Pin Pai,Masahiro Onji,Iris Uribesalgo,Reiko Hanada,Ivona Kozieradzki,Rubina Koglgruber,Shane J. F. Cronin,Zhigang She,Franz Quehenberger,Helmut Popper,Lukas Kenner,Jody J. Haigh,Jody J. Haigh,Oliver Kepp,Malgorzata Rak,Kaican Cai,Guido Kroemer,Josef M. Penninger +35 more
TL;DR: It is shown that deletion of apoptosis-inducing factor (AIF) in a KrasG12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression, and that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer.
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Autophagy in natural and therapy-driven anticancer immunosurveillance.
TL;DR: How cancer cells disable autophagy to bypass immune control and how strategies aiming to enhance autophagic can be envisaged to improve the efficacy of immunogenic cancer therapies are discussed.