K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Journal ArticleDOI
Mouse and human ornithine decarboxylase genes. Methylation polymorphism and amplification.
Leena Alhonen-Hongisto,Pekka Leinonen,Riitta Sinervirta,Raija Laine,R. Winqvist,Kari Alitalo,Olli A. Jänne,Juhani Jänne +7 more
TL;DR: The use of two restriction endonucleases, the cleavage site for both of which contains a CG sequence and which only cleave when cytosine is unmethylated indicated that ODC genes in the lymphocytic leukaemia cells were much less methylated than those in the normal leucocytes or in the Sultan cells.
Journal ArticleDOI
Immediate early gene responses of NIH 3T3 fibroblasts and NMuMG epithelial cells to TGF beta-1.
TL;DR: The results suggest that certain transcription factors are required for both positive and negative regulation of cell proliferation by TGF beta, and that their relative concentrations may determine the subsequent cellular responses.
Book ChapterDOI
Growth Factors Regulating Lymphatic Vessels
TL;DR: The lymphatics have been proposed as the main routes for tumor metastasis and are implicated in disease states such as lymphedema, inflammation, infectious and immune diseases, fibrosis and tumors such as Kaposi’s sarcoma and lymphangioma/lymphangiomatosis.
Journal ArticleDOI
Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1
Kaisa Tamminen,Diego Balboa,Sanna Toivonen,Mikko P. Pakarinen,Zoltán Wiener,Kari Alitalo,Timo Otonkoski +6 more
TL;DR: Similar hindgut and organoid cultures were established from human induced pluripotent stem cells, implying that this approach can be used to create patient-specific intestinal tissue models for disease modeling in vitro.