K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Rapid and efficient purification of Src homology 2 domain-containing proteins: Fyn, Csk and phosphatidylinositol 3-kinase p85.
TL;DR: This purification scheme was successfully applied to a third, unrelated protein that also contains the Src homology 2 (SH2) domain, namely the 85 kDa subunit of phosphatidylinositol 3-kinase, indicating that this method is versatile and should prove applicable to any protein with an accessible SH2 domain.
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Quantification of vascular endothelial growth factor-C (VEGF-C) by a novel ELISA
Herbert A. Weich,Hiroko Bando,Maren Brokelmann,Petra Baumann,Masakazu Toi,Bernhard Barleon,Kari Alitalo,Bence Sipos,Jonathan P. Sleeman +8 more
TL;DR: A specific enzyme-linked immunosorbent assay (ELISA) for the measurement of human, rat and murine VEGF-C is described and will be a useful tool for investigations concerning the physiological function of VEGf-C in lymphangiogenesis under normal and pathophysiological conditions.
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The myc proteins are not associated with chromatin in mitotic cells.
TL;DR: The results suggest that myc proteins not only bind to DNA or chromatin, but are also associated with other structural systems in the nuclei.
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Two N-myc polypeptides with distinct amino termini encoded by the second and third exons of the gene.
TL;DR: The results show that the N-myc polypeptides are initiated from two alternative in-phase AUG codons located 24 base pairs apart at the 5' end of the second exon, suggesting the close spacing of the two N- myc initiation codons could explain the relative resistance of the N -myc gene to similar modes of oncogenic activation.
Journal Article
An avian model for studies of embryonic lymphangiogenesis.
TL;DR: Using an avian model, it is shown that both intra- and extra-embryonic blood vessels of chick and quail embryos are accompanied by lymphatics, which derive from pre-existing lymphatic endothelial cells, whereas, in early embryos lymphangioblasts are present in the mesenchyme.