K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Journal ArticleDOI
Structural determinants of growth factor binding and specificity by VEGF receptor 2
Veli-Matti Leppänen,Andrea E. Prota,Michael Jeltsch,Andrey Anisimov,Nisse Kalkkinen,Tomas Strandin,Hilkka Lankinen,Adrian Goldman,Kurt Ballmer-Hofer,Kari Alitalo +9 more
TL;DR: The crystal structure of VEGF-C bound to the VEGFR-2 high-affinity-binding site is presented, which reveals a symmetrical 2∶2 complex, in which left-handed twisted receptor domains wrap around the 2-fold axis of VPDG, providing significant insights into the structural features that determine the high affinity and specificity of V EGF/VEGFR interactions.
Journal Article
BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.
Luca Tamagnone,Isto Lahtinen,Tuija Mustonen,K Virtaneva,Fiona Francis,Françoise Muscatelli,Riitta Alitalo,C. I. E. Smith,Catharina Larsson,Kari Alitalo +9 more
TL;DR: The BMX gene thus encodes a novel nonreceptor tyrosine kinase, which may play a role in the growth and differentiation of hematopoietic cells.
Journal ArticleDOI
VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications
Marius R. Robciuc,Riikka Kivelä,Ian M. Williams,Jan Freark de Boer,Theo H. van Dijk,Harri Elamaa,Feven Tigistu-Sahle,Dmitry Molotkov,Veli-Matti Leppänen,Reijo Käkelä,Lauri Eklund,David H. Wasserman,Albert K. Groen,Kari Alitalo +13 more
TL;DR: In obese and insulin-resistant mice, Vegfb gene transfer, together with endothelial Flt1 gene deletion, induced weight loss and mitigated the metabolic complications, demonstrating the therapeutic potential of the VEGFB/VEGFR1 pathway.
Journal ArticleDOI
Endothelial-specific gene expression directed by the tie gene promoter in vivo
Jaana Korhonen,Isto Lahtinen,Maria Halmekytö,Leena Alhonen,Juhani Jänne,Daniel J. Dumont,Kari Alitalo +6 more
TL;DR: The results show that the endothelial cell-type specificity of the tie promoter in vivo can be transferred to heterologous genes by using relatively short promoter fragments and has useful properties for potential gene therapy.
Journal ArticleDOI
CKIα ablation highlights a critical role for p53 in invasiveness control
Ela Elyada,Ariel Pribluda,Robert Goldstein,Yael Morgenstern,Guy Brachya,Gady Cojocaru,Irit Snir-Alkalay,Ido Burstain,Rebecca Haffner-Krausz,Steffen Jung,Zoltán Wiener,Kari Alitalo,Moshe Oren,Eli Pikarsky,Yinon Ben-Neriah +14 more
TL;DR: It is shown that the maintenance of intestinal homeostasis in CKIα-deficient gut requires p53-mediated growth control, because the combined ablation of Csnk1a1 and either p53 or its target gene p21 triggered high-grade dysplasia with extensive proliferation.