K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Oral Imatinib Mesylate (STI571/Gleevec) Improves the Efficacy of Local Intravascular Vascular Endothelial Growth Factor-C Gene Transfer in Reducing Neointimal Growth in Hypercholesterolemic Rabbits
Olli Leppänen,Juha Rutanen,Mikko Hiltunen,Tuomas T. Rissanen,Mikko P. Turunen,Tobias Sjöblom,Josef Brüggen,Gudrun Bäckström,Mari-Anne Carlsson,Elisabeth Buchdunger,David Bergqvist,Kari Alitalo,Carl-Henrik Heldin,Arne Östman,Seppo Ylä-Herttuala +14 more
TL;DR: This study provides one of the first successful examples of gene therapy combined with a pharmacological treatment to modulate 2 distinct ligand-receptor signaling systems and suggests combination of local VEGF-C gene therapy with systemic inhibition of PDGF signaling as a novel principle to prevent intimal hyperplasia after vascular manipulations.
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Biosynthesis of type V procollagen by A204, a human rhabdomyosarcoma cell line.
TL;DR: The A204 cell line, derived from a human rhabdomyosarcoma, was studied in culture for its capacity to synthesize collagen types and other extracellular matrix proteins and may prove useful in further studies of the biosynthesis of type V procollagen.
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FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase–FGFR4 complex
Nami Sugiyama,Markku Varjosalo,Pipsa Meller,Jouko Lohi,Kui Ming Chan,Zhongjun Zhou,Kari Alitalo,Jussi Taipale,Jussi Taipale,Jorma Keski-Oja,Kaisa Lehti +10 more
TL;DR: The results provide a mechanistic basis for FGFR4-R388 function in cancer invasion and identify kinases that significantly enhance MT1-MMP activity in tumor cells.
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Pulmonary Lymphangiectasia Resulting From Vascular Endothelial Growth Factor-C Overexpression During a Critical Period
Li-Chin Yao,Chiara Testini,Denis Tvorogov,Andrey Anisimov,Sara O. Vargas,Peter Baluk,Bronislaw Pytowski,Lena Claesson-Welsh,Kari Alitalo,Donald M. McDonald +9 more
TL;DR: Perinatal overexpression of VEGF-C in the respiratory epithelium led to a condition resembling human pulmonary lymphangiectasia, a life-threatening disorder of the newborn characterized by respiratory distress and the presence of widely dilated lymphatics.
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Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation.
Nami Sugiyama,Markku Varjosalo,Pipsa Meller,Jouko Lohi,Marko Hyytiäinen,Sami Kilpinen,Olli Kallioniemi,Signe Ingvarsen,Lars H. Engelholm,Jussi Taipale,Kari Alitalo,Jorma Keski-Oja,Kaisa Lehti +12 more
TL;DR: A novel mechanism of tumor progression by matrix degradation involving epithelial-to-mesenchymal transition in response to membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP-14) induction at the edge of tumors expressing the FGFR4-R388 risk variant is described.