K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Stabilized HIF-1α is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer
Katri Pajusola,Jaana Künnapuu,Sanna Vuorikoski,Jarkko Soronen,Helder André,Teresa Pereira,Petra Korpisalo,Seppo Ylä-Herttuala,Lorenz Poellinger,Kari Alitalo +9 more
TL;DR: The results show that AAV‐mediated transduction of a stabilized form of HIF‐1 α can circumvent the problems associated with overexpression of individual angiogenic growth factors, and should offer a potent alternative for pro‐angiogenic gene therapy.
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VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy
Minah Kim,Hyeung Ju Park,Jae-Won Seol,Jeon Yeob Jang,Young-Suk Cho,Kyu Rae Kim,Youngsok Choi,John P. Lydon,Francesco J. DeMayo,Masabumi Shibuya,Napoleone Ferrara,Hoon Ki Sung,Andras-Laszlo Nagy,Kari Alitalo,Gou Young Koh +14 more
TL;DR: Overall, it is shown that two key vascular growth factor receptors — VEGFR2 and Tie2 — strikingly but differentially regulate decidual angiogenesis and vascular remodelling in rapidly growing and regressing uteri in an organotypic manner.
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Net-targeted mutant mice develop a vascular phenotype and up-regulate egr-1.
Abdelkader Ayadi,Hong Zheng,Peter Sobieszczuk,Peter Sobieszczuk,Gilles Buchwalter,Philippe Moerman,Kari Alitalo,Bohdan Wasylyk +7 more
TL;DR: Results show that Net is involved in vascular biology and egr‐1 regulation in vivo and binds specifically to SRE‐5, which has been associated with pathologies involving vascular stenosis.
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Molecular lymphangiogenesis: new players.
TL;DR: An overview of the molecular players involved in lymphangiogenesis is provided, with special emphasis on recently discovered molecular mechanisms.
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Vascular Endothelial Growth Factor-B in Physiology and Disease
TL;DR: VEGF-B has the potential to induce coronary vessel growth and cardiac hypertrophy, which can protect the heart from ischemic damage as well as heart failure and is abundantly expressed in tissues with highly active energy metabolism, where it could support significant metabolic functions.