K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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MMP16 Mediates a Proteolytic Switch to Promote Cell–Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma
Olga Tatti,Erika Gucciardo,Pirita Pekkonen,Tanja Holopainen,Riku Louhimo,Pauliina Repo,Pilvi Maliniemi,Jouko Lohi,Ville Rantanen,Sampsa Hautaniemi,Kari Alitalo,Annamari Ranki,Päivi M. Ojala,Jorma Keski-Oja,Kaisa Lehti +14 more
TL;DR: A novel mechanism in melanoma pathogenesis is uncovered, whereby restricted collagen infiltration and limited mesenchymal invasion are unexpectedly associated with the properties of the most aggressive tumors, revealing MMP16 as a putative indicator of adverse melanoma prognosis.
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Structural and functional specificity of FGF receptors
TL;DR: The molecular cloning of the signal transducing receptors for fibroblast growth factors has revealed a tyrosine kinase gene family with at least four members, and the dual receptor system for FGFs might be an example of a more widely used principle.
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A fluorescent Tie1 reporter allows monitoring of vascular development and endothelial cell isolation from transgenic mouse embryos
TL;DR: Transgenic mice expressing enhanced green fluorescent protein (EGFP) or a chimeric protein consisting of a Zeosin resistance marker and EGFP under the control of mouse Tie1 promoter establish Tie1‐Z/EGFP transgenic mice as a useful model to study embryonic vascular development and a convenient source for the isolation of primary endothelial cells.
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The Basis for the Distinct Biological Activities of Vascular Endothelial Growth Factor Receptor–1 Ligands
Andrey Anisimov,Veli-Matti Leppänen,Denis Tvorogov,Georgia Zarkada,Michael Jeltsch,Tanja Holopainen,Seppo Kaijalainen,Kari Alitalo +7 more
TL;DR: It is shown that VEGF-B, unlike other VEGFs, did not require D3 interactions for high-affinity binding, and this may aid in designing VEGFR-1–targeting compounds that can inhibit or stimulate angiogenesis.
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The angiogenic and lymphangiogenic factor vascular endothelial growth factor-D exhibits a paracrine mode of action in cancer.
Marc G. Achen,Richard A. Williams,Megan E. Baldwin,Patricia Lai,Sally Roufail,Kari Alitalo,Steven A. Stacker +6 more
TL;DR: The data indicate that VEGF-D promotes tumor angiogenesis, lymphangiogenesis and metastatic spread by a paracrine mechanism.