K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
Papers
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Journal ArticleDOI
The human TYROS gene and pseudogene are located in chromosome 15q14-q25
Anne Polvi,Elina Armstrong,Gary Lai,Greg Lemke,Kay Huebner,Richard A. Spritz,Leticia C. Guida,Robert D. Nicholls,Kari Alitalo +8 more
TL;DR: Partial cDNAs of the human TYRO3 gene, encoding a putative receptor tyrosine kinase, and its processed pseudogene (TYRO3P) were cloned from human teratocarcinoma cell, bone marrow and melanocyte cDNA libraries and assigned to chromosome 15q14-q25 by analysis of DNAs from somatic cell hybrids.
Journal ArticleDOI
Endothelial tie receptor antigen in maternal and cord blood of healthy and preeclamptic subjects.
Piia Vuorela,Marja-Terttu Matikainen,Pentti Kuusela,Olavi Ylikorkala,Kari Alitalo,Erja Halmesmäki +5 more
TL;DR: The high levels of the extracellular domain of Tie in healthy term maternal and cord blood may indicate a role for Tie in the vascular development of human fetuses and placentas.
Journal ArticleDOI
KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D.
Sawan Kumar Jha,Sawan Kumar Jha,Khushbu Rauniyar,Ewa Chronowska,Ewa Chronowska,Kenny Mattonet,Eunice Wairimu Maina,Hannu Koistinen,Ulf-Håkan Stenman,Kari Alitalo,Kari Alitalo,Michael Jeltsch,Michael Jeltsch +12 more
TL;DR: A novel, unique VEGF-C form in the human reproductive system produced via cleavage by kallikrein-related peptidase 3 (KLK3), aka prostate-specific antigen (PSA), is described.
Patent
Materials and methods involving hybrid vascular endothelial growth factor dnas and proteins
Kari Alitalo,Markku M. Jeltsch +1 more
TL;DR: In this article, the authors provided polypeptides that bind cellular receptors for vascular endothelial growth factor polypepsides; polynucleotides encoding such polypeptic molecules; compositions comprising the poly peptides and polyn nucleotides; and methods and uses involving the foregoing.
Journal ArticleDOI
FLT4 receptor tyrosine kinase gene mapping to chromosome band 5q35 in relation to the t(2;5), t(5;6), and t(3;5) translocations.
Elina Armstrong,Kumar Kastury,Olga Aprelikova,Florencia Bullrich,Christian Nezelof,Jean Gogusev,John J. Wasmuth,Kari Alitalo,Steven Morris,Kay Huebner +9 more
TL;DR: It is shown that abundant FLT4 mRNA expression occurs only in erythroid and megakaryoblastoid cell lines among nine leukemia cell lines studied and that the gene is translocated to chromosomes 2 and 6 in the t(2;5)(p23;q35) and t(5;6)(q35;p21) translocations, respectively, of Ki‐1‐positive lymphomas.