K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Induction of a basement membrane glycoprotein in embryonic kidney: Possible role of laminin in morphogenesis
TL;DR: It is suggested that laminin is involved in the increased cell adhesiveness during the early aggregation of the nephrogenic mesenchyme, and in the formation of kidney tubules in mouse embryos and in an in vitro transfilter model system.
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Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis.
Toshifumi Tsurusaki,Shigeru Kanda,Hideki Sakai,Hiroshi Kanetake,Yutaka Saito,Kari Alitalo,Takehiko Koji +6 more
TL;DR: Investigation of the expression of VEGF-C and VEGFR-3 in human prostatic carcinoma tissue by using in situ hybridization and immunohistochemical staining suggests that the expression in prostatic cancers is implicated in the lymph node metastasis.
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FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1
Camilla Norrmén,Konstantin I. Ivanov,Konstantin I. Ivanov,Jianpin Cheng,Jianpin Cheng,Nadine Zangger,Mauro Delorenzi,Muriel Jaquet,Naoyuki Miura,Pauli Puolakkainen,Valerie Horsley,Valerie Horsley,Junhao Hu,Hellmut G. Augustin,Seppo Ylä-Herttuala,Kari Alitalo,Tatiana V. Petrova,Tatiana V. Petrova +17 more
TL;DR: A molecular and morphological characterization of the major steps in the maturation of the primary lymphatic capillary plexus into collecting lymphatic vessels during development is provided and show that forkhead transcription factor Foxc2 controls this process.
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Comparative Evaluation of FGF-2-, VEGF-A-, and VEGF-C-Induced Angiogenesis, Lymphangiogenesis, Vascular Fenestrations, and Permeability
TL;DR: Results show that VEGF-A stimulated formation of disorganized, nascent vasculatures as a result of fusion of blood capillaries into premature plexuses with only a few lymphatic vessels, highlighting the structural and functional differences between blood and lymphatic Vessels induced by FGF-2, VEGf-A, and V EGF-C.
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Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation
Pavel Uhrin,Jan Zaujec,Johannes M. Breuss,Damla Olcaydu,Peter Chrenek,Hannes Stockinger,Elke Fuertbauer,Markus Moser,Paula Haiko,Reinhard Fässler,Kari Alitalo,Bernd R. Binder,Dontscho Kerjaschki +12 more
TL;DR: It is shown that interaction of endothelial podoplanin of the developing lymph sac with circulating platelets from the cardinal vein is critical for separating the lymphatic from the blood vascular system.