K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
Papers
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Journal ArticleDOI
Reevaluation of the Role of VEGF-B Suggests a Restricted Role in the Revascularization of the Ischemic Myocardium
Xuri Li,Marc Tjwa,Inge Van Hove,Berndt Enholm,Elke Neven,Karri Paavonen,Michael Jeltsch,Toni Diez Juan,Richard E. Sievers,Emmanuel Chorianopoulos,Hiromichi Wada,Maarten Vanwildemeersch,Agnès Noël,Jean-Michel Foidart,Matthew L. Springer,Georges von Degenfeld,Mieke Dewerchin,Helen M. Blau,Kari Alitalo,Ulf Eriksson,Peter Carmeliet,Lieve Moons +21 more
TL;DR: VEGF-B appears to have a relatively restricted angiogenic activity in the ischemic heart, and these insights might offer novel therapeutic opportunities.
Journal ArticleDOI
Overexpression of VEGF in Testis and Epididymis Causes Infertility in Transgenic Mice: Evidence for Nonendothelial Targets for VEGF
Eija Korpelainen,Marika J. Karkkainen,Auri Tenhunen,Merja Lakso,Heikki Rauvala,Matti Vierula,Martti Parvinen,Kari Alitalo +7 more
TL;DR: Evidence that overexpression of VEGF in the testis and epididymis of transgenic mice under the mouse mammary tumor virus (MMTV) LTR promoter causes infertility is presented and it is suggested that the V EGF transgene has nonendothelial target cells in theTestis and that VEGf may regulate male fertility.
Patent
Vascular endothelial growth factor-b
TL;DR: The VEGF-B polypeptides from the PDGF family of growth factors have the property of promoting mitosis and proliferation of vascular endothelial cells and are useful in stimulating angiogenesis as well as in diagnostic applications as mentioned in this paper.
Journal ArticleDOI
Dural lymphatics regulate clearance of extracellular tau from the CNS
Tirth K. Patel,LeMoyne Habimana-Griffin,Xuefeng Gao,Baogang Xu,Samuel Achilefu,Kari Alitalo,Celia A. McKee,Patrick W. Sheehan,Erik S. Musiek,Chengjie Xiong,Dean W. Coble,David M. Holtzman +11 more
TL;DR: The dural lymphatic system appears to play an important role in clearance of extracellular tau, since tau clearance is impaired in the absence of functional lymphatics.
Journal ArticleDOI
VEGFR3 does not sustain retinal angiogenesis without VEGFR2.
TL;DR: It is found that VEGFR2 is absolutely required for the sprouting of endothelial cells that display low Notch activity, and that even small amounts of VEGfr2 are able to sustain angiogenesis to some extent.