Kari Alitalo

TL;DR: Results indicate that immunohistochemical detection of PROX1 correlates with a more malignant phenotype in rectal NETs and may be involved in progression of rectalNETs as a part of the Wnt pathway.

TL;DR: Preclinical results demonstrate that genetic TIE1 deletion in mice inhibits the vascularization and growth of tumor isografts and protects from atherosclerosis, with little effect on normal vascular homeostasis in adult mice.

TL;DR: Long-range analysis using pulsed-field gel electrophoresis revealed that the amplified L-myc locus is involved in highly complex intrachromosomal rearrangements with jal and/or rlf, and suggests that the simultaneous presence of rearrangement both in rlf intron 1 and in regions immediately upstream of L- myc may be necessary for the expression of rlf-L-myC chimeric transcripts.

TL;DR: expression of a rlf/L-myc fusion may be of critical importance in tumorigenesis by blocking differentiation and thereby allowing continued proliferation of cells and the acquisition of further mutations leading to a fully malignant tumor.

TL;DR: In this article, the authors present methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand, and the chimeric molecules of the present invention retain VEG FR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.