K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
Papers
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Journal ArticleDOI
VEGFR-1 and -2 regulate inflammation, myocardial angiogenesis, and arteriosclerosis in chronically rejecting cardiac allografts.
Olivier Raisky,Antti I. Nykänen,Rainer Krebs,M. Hollmen,Mikko A. I. Keränen,Jussi Tikkanen,Roope Sihvola,Leena Alhonen,Petri Salven,Yan Wu,Daniel J. Hicklin,Kari Alitalo,Petri Koskinen,Karl B. Lemström +13 more
TL;DR: These results suggest interplay of inflammation, primitive donor-derived myocardial angiogenesis, and arteriosclerosis in transplanted hearts, and that targeting VEGFR-1 and -2 differentially regulate these pathological reparative processes.
Journal ArticleDOI
Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury.
Johanna Magga,Laura Vainio,Teemu Kilpiö,Juha J. Hulmi,Saija Taponen,Ruizhu Lin,Markus Räsänen,Zoltan Szabo,Erhe Gao,Lea Rahtu-Korpela,Tarja Alakoski,Johanna Ulvila,Mika Laitinen,Arja Pasternack,Walter J. Koch,Kari Alitalo,Riikka Kivelä,Olli Ritvos,Risto Kerkelä,Risto Kerkelä +19 more
TL;DR: Systemic blockade of ACVR 2B ligands by ACVR2B-Fc was protective against cardiac IR injury, as evidenced by reduced infarcted area, apoptosis, and autophagy and better preserved LV systolic function following IR.
Journal ArticleDOI
SnapShot: Angiopoietins and Their Functions.
TL;DR: Key elements of angiopoietin signaling in normal and disease contexts are illustrated in this SnapShot.
Journal ArticleDOI
Identification of YAC clones for human chromosome 1p32 and physical mapping of the infantile neuronal ceroid lipofuscinosis (INCL) locus
Hellsten E,J. Vesa,Mervi Heiskanen,Tomi P. Mäkelä,Tomi P. Mäkelä,Irma Järvelä,John K. Cowell,Simon Mead,Kari Alitalo,Aarno Palotie,Leena Peltonen +10 more
TL;DR: The construction of PFGE maps on the CLN1 region covering a total of 4 Mb of this relatively poorly mapped chromosomal region is reported, providing tools for the identification of the INCL gene.
Patent
Stimulation of lymphatic growth with an FLT4 ligand
Kari Alitalo,Vladimir Joukov +1 more
TL;DR: In this paper, methods of stimulating the growth of lymphatic endothelia using an Flt 4 ligand were presented, and the results showed that the ligand was effective in stimulating lymphatic flow.