K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea
TL;DR: Results show that VEGFR-3 can mediate lymphangiogenesis induced by other growth factors, and provide a potential strategy for the inhibition of lymphatic metastasis in cancer therapy.
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The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.
M. Bergman,Tomas Mustelin,Christina Oetken,Juha Partanen,N.A. Flint,K.E. Amrein,Matti Autero,Paul Burn,Kari Alitalo +8 more
TL;DR: A human cytosolic 50 kDa protein tyrosine kinase is characterized, p50csk, which specifically phosphorylates Tyr‐505 of p56lck and a synthetic peptide containing this site, which is suggested to negatively regulates p56 lck and perhaps other cellular src family kinases.
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Isolation of the pericellular matrix of human fibroblast cultures.
TL;DR: The pericellular matrix of human fibroblast cultures was isolated, using sequential extraction with sodium deoxycholate and hypotonic buffer in the presence of protease inhibitor, and it had a vaguely filamentous ultrastructure similar to that seen in intact cell layers.
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Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2.
Krystyna Teichert-Kuliszewska,Maisonpierre Peter C,Nina Jones,Andrew I.M. Campbell,Zubin Master,Michelle P. Bendeck,Kari Alitalo,Daniel J. Dumont,George D. Yancopoulos,Duncan J. Stewart +9 more
TL;DR: The results demonstrate for the first time that Ang2 may have a direct role in stimulating Tie2 receptor signaling and inducing in vitro angiogenesis, and suggest that the physiological role of Ang2 is more complex than previously recognized.
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The related FLT4, FLT1, and KDR receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells.
Arja Kaipainen,Jaana Korhonen,Katri Pajusola,Olga Aprelikova,M G Persico,B I Terman,Kari Alitalo +6 more
TL;DR: expression of FLT4 and the other two members of this receptor family in human fetal tissues by Northern and in situ hybridization suggest that the receptor tyrosine kinases encoded by the FLT gene family may have distinct functions in the regulation of the growth/differentiation of blood vessels.