K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
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Journal ArticleDOI
Large-scale identification of genes implicated in kidney glomerulus development and function.
Minoru Takemoto,Liqun He,Jenny Norlin,Jaakko Patrakka,Zhijie Xiao,Tatiana V. Petrova,Cecilia Bondjers,Julia Asp,Elisabet Wallgard,Ying Sun,Tore Samuelsson,Petter Mostad,Samuel Lundin,Naoyuki Miura,Yoshikazu Sado,Kari Alitalo,Susan E. Quaggin,Karl Tryggvason,Christer Betsholtz +18 more
TL;DR: It is shown that Foxc2 controls the expression of a distinct set of podocyte genes involved in podocyte differentiation and glomerular basement membrane maturation, and surmise that studies on the other novel glomerulus‐enriched transcripts identified in this study will provide new insight intoglomerular development and pathomechanisms of disease.
Journal ArticleDOI
Use of cancer‐specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors
David J. McBride,Arto Orpana,Christos Sotiriou,Heikki Joensuu,Philip J. Stephens,Laura Mudie,Eija Hämäläinen,Eija Hämäläinen,Lucy Stebbings,Leif C. Andersson,Adrienne M. Flanagan,Adrienne M. Flanagan,Virginie Durbecq,Michail Ignatiadis,Olli Kallioniemi,Caroline A. Heckman,Kari Alitalo,Henrik Edgren,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Peter J. Campbell +21 more
TL;DR: Next‐generation sequencing now allows rapid identification of patient‐specific rearrangements in solid tumors, and it is shown that PCR assays for rearrangement could detect a single copy of the tumor genome in plasma without false positives.
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Endothelial destabilization by angiopoietin-2 via integrin β1 activation
Laura Hakanpaa,Tuomas Sipilä,Veli-Matti Leppänen,Prson Gautam,Harri Nurmi,Guillaume Jacquemet,Lauri Eklund,Johanna Ivaska,Kari Alitalo,Pipsa Saharinen +9 more
TL;DR: These results establish Ang2-mediated β1-integrin activation as a promoter of endothelial destablization, explaining the controversial vascular functions of Ang1 and Ang2.
Journal ArticleDOI
cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels
Lukas Stanczuk,Lukas Stanczuk,Ines Martinez-Corral,Ines Martinez-Corral,Maria H. Ulvmar,Yang Zhang,Barbbara Lavina,Marcus Fruttiger,Ralf H. Adams,Dieter Saur,Dieter Saur,Christer Betsholtz,Christer Betsholtz,Sagrario Ortega,Kari Alitalo,Mariona Graupera,Taija Makinen,Taija Makinen +17 more
TL;DR: It is shown that the vascular endothelial growth factor receptor 3/p110α PI3-kinase signaling pathway is selectively required for the formation of mesenteric lymphatic vasculature, which may critically underlie organ-specific manifestation of lymphatic dysfunction in disease.
Journal ArticleDOI
Plasmin Activates the Lymphangiogenic Growth Factors VEGF-C and VEGF-D
Bradley McColl,Megan E. Baldwin,Sally Roufail,Craig Freeman,Robert L. Moritz,Richard J. Simpson,Kari Alitalo,Steven A. Stacker,Marc G. Achen +8 more
TL;DR: It is reported that the serine protease plasmin cleaved both propeptides from the V EGF homology domain of human VEGF-D and thereby generated a mature form exhibiting greatly enhanced binding and cross-linking of VEGFR-2 and V EGFR-3 in comparison to full-length material.