K
Kari Alitalo
Researcher at University of Helsinki
Publications - 844
Citations - 122462
Kari Alitalo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor C. The author has an hindex of 174, co-authored 817 publications receiving 114231 citations. Previous affiliations of Kari Alitalo include Mount Sinai Hospital, Toronto & Cornell University.
Papers
More filters
Journal ArticleDOI
Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell–Cell Junctions and Lung Metastasis
Tanja Holopainen,Pipsa Saharinen,Gabriela D'Amico,Anita Lampinen,Lauri Eklund,Raija Sormunen,Andrey Anisimov,Georgia Zarkada,Marja Lohela,Hanna Heloterä,Tuomas Tammela,Laura Benjamin,Seppo Ylä-Herttuala,Ching Ching Leow,Gou Young Koh,Kari Alitalo +15 more
TL;DR: The effects of angiopoietin-2 on tumor lymphangiogenesis and metastasis are poorly characterized as mentioned in this paper. But, Ang2 is a ligand for endothelial TEK (Tie2) tyrosine kinase receptor.
Journal Article
Serum vascular endothelial growth factor is often elevated in disseminated cancer.
TL;DR: The results indicate that both patients with locoregional cancer and patients with disseminated cancer may have elevated VEGF levels, regardless of the histological type of cancer, and that S-VEGF is often elevated in cancer with distant metastases.
Journal ArticleDOI
Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes
Anne Saaristo,Tanja Veikkola,Berndt Enholm,Maija Hytönen,Johanna Arola,Katri Pajusola,Päivi Turunen,Michael Jeltsch,Marika J. Karkkainen,Dontscho Kerjaschki,Hansruedi Büeler,Seppo Ylä-Herttuala,Kari Alitalo +12 more
TL;DR: Results show that virally produced V EGF‐C induces blood vessel changes, including vascular leak, but its angiogenic potency is much reduced compared with VEGF in normal skin.
Journal ArticleDOI
Role of lymphangiogenic factors in tumor metastasis
TL;DR: A review of the recent developments in lymphatic vessel development concludes that Vascular endothelial growth factor C (VEGF-C) and VEGF-D, via signaling through VEGFR-3, appear to be essential for lymphatic vessels growth.
Journal ArticleDOI
Preexisting Lymphatic Endothelium but not Endothelial Progenitor Cells Are Essential for Tumor Lymphangiogenesis and Lymphatic Metastasis
Yulong He,Iiro Rajantie,Maritta Ilmonen,Taija Makinen,Marika J. Karkkainen,Paula Haiko,Petri Salven,Kari Alitalo +7 more
TL;DR: It is demonstrated that during tumor lymphangiogenesis and cancer cell dissemination via the lymphatics, the newly formed lymphatic vessels sprout from the pre-existing local lymphatic network with little if any incorporation of BM-derived endothelial progenitor cells.